【摘要】 目的:探讨男性精神分裂症患者尼古丁依赖水平与认知功能的相关性。方法:将80例男性精神分裂症住院患者根据吸烟状况分为吸烟组和不吸烟组,采用一般情况调查表、自编吸烟情况调查表、尼古丁依赖检测量表(FTND)、神经认知功能测验(MCCB)和阳性阴性症状量表(PANSS)进行测试。结果:吸烟组与不吸烟组在工作记忆、推理和问题解决方面差异有统计学意义(P<0.05)。在吸烟组中,年龄与视觉学习和问题推理存在正相关(P<0.05),与处理速度、言语学习、社会认知存在负相关(P<0.05);病程与视觉学习存在正相关(r=0.328,P<0.05),与处理速度、注意警觉、言语学习、社会认知存在负相关(P<0.05);PANSS评分与处理速度、注意警觉、言语学习、视觉学习、社会认知存在负相关(P<0.05);受教育年限与工作记忆、视觉记忆存在正相关(P<0.05),与言语学习存在负相关(P<0.05);吸烟量与工作记忆、问题推理存在正相关(P<0.05);吸烟年限与工作记忆、视觉学习、问题推理存在正相关(P<0.05);FTND水平与工作记忆、视觉学习、问题推理存在正相关(P<0.05)。结论:吸烟组精神分裂症男性患者的工作记忆和问题推理能力更好。吸烟量、吸烟时间及尼古依赖水平均与工作记忆、问题推理存在正相关。更多还原

【Abstract】 Objective:To investigate the correlation between nicotine dependence level and cognitive function in male patients with schizophrenia.Methods:Eighty 80 hospitalized male schizophrenic patients were divided into smoking group and non-smoking group according to their smoking status.All patients underwent measurement with general condition questionnaire, self-programmed smoking status questionnaire, fagerstrom test of nicotine dependence(FTND),matrics consensus cognitive battery(MCCB),and positive & negative symptoms scale(PANSS).Results:There were significant differences in working memory, reasoning, and problem solving between the smoking and non-smoking groups(P<0.05).Age was positively correlated with visual learning and problem reasoning(P<0.05),yet negatively with processing speed, speech learning and social cognition(P<0.05).The course of disease was in positive correlation with visual learning(P<0.05),and in negative correlation with processing speed, attention alert, speech learning, and social cognition(P<0.05).Scoring on PANSS was negatively correlated with processing speed, attention alert, verbal learning, visual learning, and social cognition(P<0.05).Years of education were in positive correlation with working memory and visual memory(P<0.05),yet in negative correlation with speech learning(P <0.05).There was a positive correlation between smoking amount and working memory and problem reasoning(P<0.05).Years of smoking were positively correlated with working memory, visual learning and problem reasoning(P<0.05).The level of FTND was positively correlated with working memory, visual learning and problem reasoning(P<0.05).Conclusion:Patients with schizophrenia in the smoking group are better on working memory and problem reasoning.And smoking amount, duration and nicotine dependence level are positively correlated with working memory and problem reasoning.更多还原