【摘要】 目的探讨血浆中二氯二苯二氯乙烯(DDE)水平与阿尔茨海默病(AD)患者脑脊液生物标志物的相关性。方法检索阿尔茨海默病神经影像学倡议数据库(ADNI),获得符合纳入标准的研究对象207例(男111例,女96例),分为AD组和健康对照组。采用多元线性回归分析分析血浆中DDE水平与AD患者脑脊液中生物标志物[脑脊液β-淀粉样蛋白(Aβ)、tau蛋白、磷酸化tau(p-tau)蛋白]的相关性,并将研究对象按照性别分为不同亚组,分析不同性别亚组中血浆中DDE水平与AD患者脑脊液标志物的相关性。结果两组研究对象血浆中DDE水平与AD患者脑脊液中生物标志物无相关性(P>0.05)。多元线性回归分析显示,在血浆DDE与性别交互作用下,血浆中DDE水平与AD患者脑脊液Aβ水平呈显著负相关(b=-20.913,P<0.05);亚组分析结果显示,血浆中DDE水平与男性AD患者脑脊液的Aβ水平呈显著负相关(b=-21.919,P<0.05),与女性AD患者脑脊液标志物均无显著相关性(P>0.05)。结论男性人群暴露在DDE环境下患AD的风险增加,可能与男性人群暴露于DDE环境的机会多、时间长有关。更多还原

【Abstract】 Objective To explore the correlation between plasma dichlorodiphenyldichloroethylene(DDE) and cerebrospinal fluid biomarkers of Alzheimer’s disease(AD). Methods A total of 207 subjects(111 males and 96 females) were selec-ted from the Alzheimer’s Disease Neuroimaging Initiative(ADNI) database and divided into AD group and healthy control group. A multiple linear regression analysis was used to evaluate the correlation between plasma DDE and cerebrospinal fluid biomarkers [amyloid β-protein(Aβ), tau protein, and p-tau protein] of AD patients. The subjects were categorized into sex subgroups for the same analysis. Results There was no correlation between plasma DDE and cerebrospinal fluid biomarkers in AD patients(P>0.05). The multiple linear regression analysis including the interaction of plasma DDE and sex showed a significant negative correlation between plasma DDE and cerebrospinal fluid beta-amyloid(b=-20.913,P<0.05). Subgroup analysis showed that plasma DDE was significantly negatively correlated with cerebrospinal fluid beta-amyloid in male patients(b=-21.919,P<0.05), while no significant correlation was detected in female patients(P>0.05). Conclusion The increased risk of AD in males exposed to DDE may be explained by their increased exposure frequency and duration.更多还原