【摘要】 为研究不同剂量25羟基维生素D₃[25（OH）VD₃]对断奶前犊牛血液水平、抗氧化能力和免疫功能的影响,选取18头健康状况良好的新生荷斯坦犊牛,随机分成3组,每组6头进行为期56天的饲养试验。分为对照组[不添加25（OH）VD₃]、低剂量组[25（OH）VD₃添加量6 000 IU/头·天]和高剂量组[25（OH）VD₃添加量12 000 IU/头·天]。结果表明,与对照组相比,随着25（OH）VD₃添加剂量增加,血浆生长激素、胰岛素样生长因子-1、过氧化氢酶、超氧化物歧化酶、总抗氧化能力以及免疫球蛋白G（IgG）含量显著增加（P<0.05）,而丙二醛含量随剂量增加而存在降低趋势（P=0.079）。与对照组和低剂量组相比,高剂量组血浆免疫球蛋白A（IgA）含量有增加趋势（P=0.059）。综上所述,断奶前犊牛饲喂高剂量25（OH）VD₃有利于促进体内生长激素和胰岛素样生长因子-1分泌,可提高犊牛抗氧化能力,增强免疫功能。更多还原

【Abstract】 To study the effects of 25-hydroxyvitamin D₃ [25（OH）VD₃] at different doses on blood level,antioxidant capacity and immune function of pre-weaning calves,18 healthy Holstein calves were randomly assigned to 3 groups with 6 calves in each group for 56 days. They were divided into control group [0 IU 25（OH）VD₃ per calf per day], low-dose group [6 000 IU 25（OH）VD₃ per calf per day] and high-dose group [12 000 IU 25（OH）VD₃ per calf per day]. The results showed that compared with the control group, the contents of plasma growth hormone, insulin-like growth factor-1, catalase, superoxide dismutase,total antioxidant capacity and immunoglobulin G（IgG） were significantly increased（P <0.05） with the increasing dose of 25（OH）VD₃. The content of malondialdehyde decreased with the dosage of 25（OH）VD₃ increased（P =0.079）. Compared with the control group and the low-dose group, the plasma immunoglobulin A（IgA） content in the high-dose group had an increasing trend（P=0.059）. In conclusion,feeding high doses of 25（OH）VD₃ to calves before weaning can promote the secretion of growth hormone and insulin-like growth factor-1,improve antioxidant capacity, and enhance immune function.更多还原