【摘要】 目的探讨亚临床剂量盐酸艾司氯胺酮注射液在孕产妇腰硬联合麻醉(CESA)剖宫产术中的应用效果。方法选取2020年3月至2021年5月郑州市妇幼保健院和郑州市第一人民医院收治的60例剖宫产孕产妇,按照随机数表法分为观察组和对照组,各30例。对照组接受盐酸罗哌卡因,观察组在对照组基础上接受亚临床剂量盐酸艾司氯胺酮注射液。对比两组麻醉生效及恢复时间、麻醉效果及不良反应情况。结果干预后两组感觉阻滞和运动阻滞生效时间及感觉和运动恢复时间比较,差异无统计学意义(P>0.05);观察组总有效率为100%,对照组为86.67%,观察组麻醉效果优于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论亚临床剂量盐酸艾司氯胺酮注射液在孕产妇CSEA剖宫产术中能够提高术中镇痛作用,麻醉效果较好,值得临床推广。更多还原

【Abstract】 Objective To investigate the effectiveness of subclinical dose of esketamine hydrochloride injection in cesarean section with combined spinal-epidural anesthesia(CSEA) for pregnant women.Methods From March 2020 to May 2021, 60 cases of pregnant women undergoing cesarean section were selected from Women & Infants Hospital of Zhengzhou and Zhengzhou First People’s Hospital. They were divided into observation group and control group according to the random number table method, 30 cases in each group. The control group received ropivacaine hydrochloride, and the observation group received a subclinical dose of esketamine hydrochloride injection on the basis of the control group. The anesthesia effect and recovery time, anesthesia effect and adverse reactions were compared between the two groups.Results There were no statistical differences in the effective time of sensory block and motor block and the recovery time of sensory and motor block between the two groups(P>0.05). The total effective rate of observation group was 100.00%, and that of control group was 86.67%, and the anesthesia effect of observation group was better than that of control group(P<0.05). There was no statistical difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of subclinical dose of esketamine hydrochloride injection during CSEA cesarean section of pregnant and lying-in women can improve intraoperative analgesia and enhance the effect of anesthesia, which is worthy of clinical promotion.更多还原