【摘要】 <正>糖尿病属于多病因的代谢性疾病,显著临床特征为慢性高血糖,并常伴有糖、脂肪和蛋白质代谢紊乱。随着患病时间延长,若病人体内代谢紊乱得不到很好地控制,容易产生心脑血管疾病、肾功能衰竭、肢体坏疽和昏迷等并发症[1]。中草药在治疗糖尿病上具有独特疗效[2],从中草药资源中寻找治疗糖尿病及其并发症的天然产物已成为研究热点[2]。枇杷[Eriobotrya japonica (Thunb.) Lindl.]干燥叶为常用中药材,具有清肺止咳和降逆止更多还原

【Abstract】 In vitro inhibitory effects of six triterpene acids（including euscaphic acid, tormentic acid, corosolic acid, maslinic acid, oleanolic acid, and ursolic acid） from leaf of Eriobotrya japonica（Thunb.） Lindl. on α-glucosidase activity and production of nonenzymatic glycosylation products Amadori and AGEs were studied. The results show that the six triterpene acids have strong inhibitory effects on α-glucosidase activity, with semi-inhibitory concentration(IC₅₀) of 0.76-35.45 μg·mL^-1, in which, ursolic acid has the strongest inhibitory effect. The six triterpene acids show inhibitory effects on Amadori formation, and the inhibitory effects decrease significantly with the decrease of mass concentration, in which, 50 μg·mL^-1 euscaphic acid has the strongest inhibitory effect, with inhibition rate of 83.63%; however, the six triterpene acids have no evident inhibitory effect on AGEs formation, and the inhibition rate of 50 μg·mL^-1 euscaphic acid has the strongest inhibitory effect, but the inhibition rate is only 18.71%. In conclusion, triterpene acids from leaf of E. japonica have potential therapeutic effects on diabetes and its complications.更多还原