【摘要】 近年来,登革病毒在全球热带与亚热带地区暴发流行,感染例数居高不下,严重危害了公共卫生安全。在登革病毒感染后,宿主细胞迅速激活多条信号通路,以应对和抵御病毒的入侵;另一方面,登革病毒演化出多种逃逸、拮抗甚至利用细胞应答的策略。本综述简要综述了登革病毒的分子生物学,以及细胞抗病毒的应答(包括固有免疫应答、适应性免疫应答、细胞死亡、自噬、未折叠蛋白反应、应激颗粒形成)的研究现状。更多还原

【Abstract】 Recent outbreak of dengue virus(DENV) in subtropics and tropics and the increasing incidence of DENV infection have seriously threatened the public health. Upon virus infection,the host cells rapidly elicit various responses through activating different signaling pathways,to fight against the invasion of DENV. On the other hand,dengue virus has evolved many strategies of escaping,antagonizing or even utilizing these host responses. This review summarizes the progress of molecular biology of DENV and the cellular responses against DENV infection,including innate immune response,adaptive immune response,cell death,autophagy,unfolded protein response,and stress granule formation.更多还原