【摘要】 目的优化法莫替丁胃漂浮控释片的处方,并评价其漂浮和体外释放特性。方法采用星点设计-效应面法优化片剂的处方,制备法莫替丁胃漂浮控释片,并考察其漂浮行为与体外释放特性。结果优化的处方为每片含法莫替丁40 mg,WSR 303 138 mg,Eudragit L100-55 62 mg,NaHCO₃ 74 mg。该处方片剂硬度为5～7kg,体外持续释药达24 h以上,符合零级释放模型。结论该片剂具有漂浮、控释作用,且制备工艺简单。更多还原

【Abstract】 Objective To screen and optimize the formulation of farmotidine gastric floating controlled release tablets, and evaluate their floating and in vitro release. Methods Central composite design-response surface method was used to optimize the formulation of farmotidine gastric floating controlled release tablets, and their release mechanism and floating characteristics were studied. Results The optimized formulation included famotidine 40 mg, WSR 303 138 mg, Eudragit L100-55 62 mg, and NaHCO₃ 74 mg per tablet. The prescription tablet had a hardness of 5-7 kg, and the in vitro sustained release was longer than 24 h with the release rate conformed to zero-grade release model. Conclusion The tablets show levitation and controlled release, with simple preparation process.更多还原