【摘要】 近年来,结构性磁共振成像(sMRI)和功能性磁共振成像(fMRI)被广泛应用于抑郁症研究。从结构形态学、结构网络、功能网络3个角度探索抑郁症患者的大脑异常,了解其发病机制,辅助医生临床诊断、治疗和预后。目前大量研究发现抑郁症患者的海马体、杏仁核出现不同程度的萎缩,脑网络的连接强度、图论属性等均出现显著异常,且出现异常的脑区对应于人的情绪调节、注意力和认知控制等功能,异常的程度与抑郁的严重程度呈现高度相关性。从不同角度对抑郁症的研究现状进行综述,并对未来的研究提出了建议。更多还原

【Abstract】 In recent years, structural magnetic resonance imaging(sMRI) and functional magnetic resonance imaging(fMRI) are widely used in depression research. From the perspectives of morphology, structural network and functional network, the brain abnormalities of depression were explored to understand the pathogenesis, and to assist doctors in clinical diagnosis, treatment and prognosis. A large number of researches have found that the hippocampus and amygdala of depression showed different degrees of atrophy, and the connection strength of brain network and graph theory attributes showed significant abnormal. Moreover, the abnormal brain areas were related to emotional regulation, attention and cognitive control, and the degree of abnormalities were highly correlated with the severity of depression. The research actuality of depression from different perspectives was reviewed, and some suggestions for future research were put forward.更多还原