【摘要】 成骨细胞是骨组织中重要的的刺激感受细胞和效应细胞,参与多种力学刺激下骨的修复及重建。流体剪切应力是人体内骨组织受到的最直接的力学刺激,已有大量研究证明流体剪切应力可以通过激活Wnt信号通路、BMP-Smad依赖性信号通路或BMP-非Smad依赖性信号通路促进成骨细胞增殖分化。近年来,越来越多的研究发现流体剪切应力还可以通过激活ERK5信号通路、PI3K/AKT激酶信号通路等途径抑制成骨细胞凋亡,这为流体剪切应力促进成骨细胞增殖提供了一个新的研究方向。本文就近年来流体剪切应力促进成骨细胞增殖的影响机制作一综述,希望能为骨科相关疾病的防治及研究提供参考。更多还原

【Abstract】 Osteoblasts are important stimulator cells and effector cells in bone tissue, which involve in bone repair and reconstruction under various mechanical stimulation. Fluid shear stress is the most direct mechanical stimulation of human bone tissue. A large number of studies have shown that fluid shear stress can promote the proliferation and differentiation of osteoblasts by activating Wnt signal pathway, BMP-Smad dependent signal pathway or BMP-Smad independent signal pathway. In recent years, more and more studies have found that fluid shear stress can also inhibit osteoblast apoptosis by activating ERK5 signaling pathway and PI3 K/AKT kinase signaling pathway. This provides a new research direction for fluid shear stress to promote osteoblast proliferation. In this paper, the mechanism of fluid shear stress promoting osteoblast proliferation in recent years is reviewed to provide a reference for the prevention and treatment of orthopedic diseases.更多还原