【摘要】 绝经后骨质疏松症是由于雌激素降低导致钙吸收增加、骨量减少而引发的代谢性骨骼疾病,骨折是该病的主要发现途径,严重影响着中老年人身心健康。目前常用的西药主要包括钙剂、双膦酸盐类、骨吸收抑制剂等,但其副作用和不良反应限制了长期用药。如今大量研究表明,中药可通过作用于成骨相关的多通路、多靶点,有效提高骨密度,减轻骨痛,在防治绝经后骨质疏松症上有独特优势。笔者从临床、动物、细胞等方面归纳中药及复方防治绝经后骨质疏松症的研究进展,以期为临床防治该病提供借鉴。更多还原

【Abstract】 Postmenopausal osteoporosis is a metabolic bone disease caused by increase of calcium intake and decrease of bone mass due to decreased estrogen. Fracture is the main discovery pathway of the disease,which seriously affects the physical and mental health of middle-aged and elderly people. At present,the use of Western medicine is mainly calcium,bisphosphonates,bone resorption inhibitors,etc.,but the side effects and adverse reactions limit their long-term use. Nowadays,many studies have shown that traditional Chinese medicine effectively increases bone mineral density and reduce bone pain by acting on pathways and targets related to osteogenesis,which has unique advantage in the prevention and treatment of postmenopausal osteoporosis. In this paper,the research progress of traditional Chinese medicine and compound prescription in the prevention and treatment of postmenopausal osteoporosis is summarized from the aspects of clinical,animal,and cell,in order to provide reference for clinical prevention and treatment of this disease.更多还原