【摘要】 目的分析复方甘草酸苷联合盐酸左西替利嗪治疗皮炎湿疹的效果及对Th1/Th2型细胞因子的影响。方法选取2018年10月～2019年10月于我院接受治疗的皮炎湿疹患者80例,分为对照组(40例)和观察组(40例)。两组采取不同的方法进行治疗,其中对照组采取盐酸左西替利嗪治疗,观察组采取复方甘草酸苷联合盐酸左西替利嗪治疗。治疗后比较两组患者的Th1/Th2型细胞因子水平指标及临床疗效。结果治疗后,观察组的Th1型细胞因子中的IFN-γ及IL-2明显高于对照组,差异有统计学意义(P<0.05)。观察组的Th2型细胞因子中的IL-4、Ig E与对照组比较,差异有统计学意义(P<0.05)。治疗后,观察组的瘙痒症状分数及糜烂症状分数与对照组比较,差异有统计学意义(P<0.05)。观察组的总有效率明显高于对照组(P<0.05)。结论对皮炎湿疹患者进行治疗的过程中,使用复方甘草酸苷联合盐酸左西替利嗪进行治疗能够有效改善患者Th1、Th2型细胞炎症因子,疗效确切,值得推广和应用。更多还原

【Abstract】 Objective To analyze and study the effect of compound glycyrrhizin combined with levocetirizine hydrochloride in the treatment of dermatitis and eczema and its influence on Th1/Th2 cytokines. Methods A total of 80 patients with dermatitis and eczema treated in our hospital from October 2018 to October 2019 were selected. The patients were divided into the control group(40 cases) and the observation group(40 cases) using a random number table method.The two groups were treated with different treatment methods. The control group was treated with levocetirizine hydrochloride, and the observation group was treated with compound glycyrrhizin combined with levocetirizine hydrochloride. After treatment, the Th1/Th2 cytokine levels and clinical efficacy between the two groups of patients were compared, summarized and analyzed. Results After treatment, the IFN-γ and IL-2 in Th1 type cytokines of the observation group were significantly higher than those in the control group, and the difference was statistically significant(P<0.05).There were significant differences in the IL-4 and IgE in Th2 type cytokines between the observation group and the control group(P<0.05). After treatment, the differences in the scores of pruritus and erosions between the observation group and the control group were statistically significant( P<0.05). The total effective rate of the observation group was significantly higher than that of the control group(P<0.05). Conclusion In the process of treating patients with dermatitis and eczema, the use of compound glycyrrhizin combined with levocetirizine hydrochloride can effectively improve the inflammatory factors of Th1 and Th2. It has curative effect and is worthy of clinical adoption.更多还原