【摘要】 目的探讨甘草酸二铵联合还原型谷胱甘肽治疗阿维A导致药物性肝损伤的疗效。方法选取2019年1~12月口服阿维A所致药物性肝损伤患者65例,随机分为两组(治疗组32例,对照组33例),其中治疗组给予甘草酸二铵(甘草酸二铵150 mg+10%葡萄糖注射液250 mL,静点每日一次)联合还原型谷胱甘肽(还原型谷胱甘肽1.8 g+10%葡萄糖注射液250 mL,静点每日一次)治疗,2周为一疗程;对照组单独给予还原型谷胱甘肽治疗(用法剂量疗程与治疗组相同)。观察治疗前后两组患者肝功能(ALP、GGT、ALT等)和TG(血脂)的变化,比较两组临床疗效及不良反应。结果治疗后,两组患者肝功能指标和血脂均有显著改善,治疗组患者肝功能指标和血脂(甘油三酯)改善程度显著优于对照组,差异有统计学意义(P<0.05);治疗组治疗总有效率显著高于对照组;两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论甘草酸二铵联合还原型谷胱甘肽治疗阿维A导致药物性肝损伤可显著改善患者肝功能并降低血脂,治疗总有效率高、不良反应少,适宜推广应用。更多还原

【Abstract】 Objective To explore the therapeutic effect of diammonium glycyrrhizinate combined with reduced glutathione in the treatment of drug-induced liver injury caused by retinoin A. Methods From January to December 2019,65 patients with drug-induced liver injury caused by oral Avita A were randomly divided into two groups(32 in the treatment group and 33 in the control group), of which the treatment group was given diammonium glycyrrhizinate(diammonium glycyrrhizinate 150 mg+10% glucose injection 250 mL, once a day) combined with reduced glutathione(reduced glutathione 1.8 g+10% glucose injection 250 mL, once a day). Two weeks was a course of treatment. The control group was given reduced glutathione alone(the dosage and dosage of the control group was the same as that of the treatment group). The changes of liver function(ALP, GGT, ALT, etc.) and TG(blood lipid) of the two groups of patients before and after treatment were observed. The clinical efficacy and adverse reactions were comgared between the two groups. Results After treatment, the liver function indexes and blood lipids of the two groups were significantly improved. The liver function indexes and blood lipids(triglycerides) of the treatment group were significantly better than those of the control group, and the difference was statistically significant(P<0.05). The total treatment effective rate of the treatment group was significantly higher than that in the control group. There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Diammonium glycyrrhizinate combined with reduced glutathione in the treatment of retinoic acid-induced liver injury can significantly improve the liver function of patients and reduce blood lipids, with a high effective rate of treatment and fewer adverse reactions,which is suitable for popularization and application.更多还原