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沙库巴曲缬沙坦治疗老年左室射血分数降低心力衰竭的效果
Effect of Sakubatrevalsartan in the treatment of heart failure in the elderly with left ventricular ejection fraction reduction
【摘要】 目的观察沙库巴曲缬沙坦治疗老年左室射血分数(LVEF)降低心力衰竭的效果。方法选取2017年6月~2018年12月柳州市人民医院收治的老年LVEF降低心力衰竭患者89例,采用随机数字表法将患者分为对照组(n=44)和研究组(n=45),对照组给予常规西医治疗,研究组在对照组的基础上联合沙库巴曲缬沙坦治疗。比较两组临床疗效、心功能指标、肾功能指标及不良反应情况。结果研究组治疗后的临床总有效率显著高于对照组(P <0.05)。两组治疗后6 min步行试验距离长于治疗前,左心室舒张末期内径短于治疗前,LVEF高于治疗前,心率慢于治疗前,且研究组改善情况明显优于对照组(P <0.05)。两组治疗后尿素氮、肌酐均低于治疗前,估算的肾小球滤过率高于治疗前,且研究组改善情况明显优于对照组(P <0.05)。两组不良反应发生率比较差异无统计学意义(P> 0.05)。结论沙库巴曲缬沙坦治疗老年LVEF降低心力衰竭可有效改善患者心、肾功能,疗效确切,且安全性较好,具有一定的临床应用价值。
【Abstract】 Objective To observe the effect of Sakubatrevalsartan in the treatment of heart failure in the elderly with left ventricular ejection fraction(LVEF) reduction.Methods 89 elderly patients with heart failure were selected from Liuzhou People’s Hospital from June 2017 to December 2018,they were divided into control group(n=44) and study group(n=45) by random number table method.Control group was treated with routine Western medicine,and study group was treated with Sakubatrevalsartan on the basis of control group.Clinical efficacy,cardiac function,renal function and adverse reactions were compared between two groups.Results After treatment,total effective rate of study group was significantly higher than that of control group(P <0.05).The walking distance of 6 minutes after treatment in two groups was longer than that before treatment,left ventricular end diastolic dimension was shorter than that before treatment,LVEF was higher than that before treatment,heart rate was slower than that before treatment,and the improvement in study group was significantly better than that in control group(P <0.05).After treatment,blood urea nitrogen and serum creatinine of two groups were lower than before treatment,estimated glomerular filtration rate was higher than before treatment,and the improvement of study group was significantly better than that of control group(P <0.05).There was no significant difference in the incidence of adverse reactions between two groups(P> 0.05).Conclusion Sakubatrevalsartan can effectively improve the cardiac and renal function of elderly patients with heart failure due to the reduction of LVEF,with definite curative effect and good safety,and has certain clinical application value.
【Key words】 Heart failure; Sakubatrevalsartan; Left ventricular ejection fraction reduction; Elderly;
- 【文献出处】 中国医药导报 ,China Medical Herald , 编辑部邮箱 ,2020年08期
- 【分类号】R541.6
- 【被引频次】12
- 【下载频次】80