【摘要】 整合素(integrin)是一类重要的细胞表面黏附分子,由α和β亚基通过非共价键组成异源二聚体,对于免疫细胞的组织定位、凝血、癌细胞转移以及组织和器官的发育等都至关重要。整合素的胞内结构域通常很短,但是却可以结合多种细胞内信号蛋白,对整合素介导的"outside-in"和"inside-out"信号通路发挥重要作用。因此,筛选和鉴定可以特异性识别整合素胞内结构域的调控蛋白,对阐明整合素介导双向信号转导的机制尤为重要。该文系统地总结了可以分别结合整合素α亚基和β亚基的胞内调控蛋白,分别从各个蛋白的分子结构、在整合素胞内段的结合位点、调控机制以及生理和病理功能等方面做了详尽的阐释,并对整合素胞内调控蛋白的临床应用前景作出展望。更多还原

【Abstract】 Integrin is an important cell surface adhesion molecule,which is a heterodimer formed by α and β subunits through non-covalent bonds and is very important for the localization of immune cells,blood coagulation,metastasis of cancer cells,and the development of tissues and organs.Although the cytoplasmic domain of integrin is usually very short,it can bind with many intracellular regulatory proteins,which plays vital roles in integrin-mediated outside-in and inside-out signalings.Thus,screening and identification of regulatory proteins specifically recognizing integrin cytoplasmic domain can help to illuminate the mechanism of how integrin regulates the bidirectional signal transduction.In this study,the integrin intracellular regulatory proteins were systematically summarized,which interacted with integrin α and β subunits,respectively.The molecular structure,binding site in integrin cytoplasmic domain,regulatory mechanism,and physiological and pathological functions of each protein were introduced in detail.In the end,the clinical application of integrin intracellular regulatory protein was prospected.更多还原