【摘要】 目的:以多导睡眠脑电图(PSG)为主要技术方法,观察RBD患者各种并发症的发生率,以期进一步探讨与RBD发生相关的危险因素。方法:回顾性分析2015年10月至2018年12月广州市第一人民医院睡眠中心行PSG监测的患者723例作为研究对象,筛选经PSG确诊为RBD者,统计RBD及其各种并发症的发生率并进行相关分析。结果:1) 723例患者中有120例经PSG确诊为RBD(约16. 6%)。其中,无并发症者17例(约14. 2%);合并神经系统变性病者39例(约32. 5%)、高血压病者38例(约31. 7%)、情感障碍者36例(约30. 0%)、合并情感障碍且无变性病者27例(约22. 5%)、糖尿病者22例(约18. 3%)、脑梗死者19例(约15. 8%)、高脂血症者14例(约11. 7%)、冠心病者10例(约8. 3%);合并紧张性头痛、血管性痴呆、癫痫者各3例(各占约2. 5%);另有合并其他疾病如5-HT综合征、缺血缺氧性脑病等各占约0. 8%。2)研究中,合并神经系统变性病的39例RBD患者中,合并PLMS者19例(占48. 7%); 120例RBD患者中,存在周期性肢体运动者46例,占约38. 3%,其中合并神经系统变性病者19例,占41. 3%;无周期性肢体运动者74例,其中合并神经系统变性病者20例,占27. 0%。结论:1) RBD患者中神经系统变性病、高血压病、情感障碍、糖尿病、脑梗死、高脂血症、冠心病等多种并发症的发生率均较高,其中以神经系统变性病为首。2) RBD患者中同时存在周期性肢体运动可能提示更高的神经系统变性病发生风险。更多还原

【Abstract】 Objective: To observe the incidence of various complications in RBD patients with polysomnography( PSG) as the main technique,so as to further explore the risk factors related to the occurrence of RBD. Methods: A total of 723 patients who underwent PSG monitoring in the sleep center of our hospital from October 2015 to December 2018 were reviewed. Those who were diagnosed as RBD by PSG were screened. The incidence of RBD and its complications was analyzed. Results: 1) Among the 723 patients,120 were confirmed as RBD by PSG( about 16. 6%). Among them,there were 17 cases( about 14. 2%) without complications. There were 39 cases( 32. 5%) with neurodegenerative disease,38 cases( 31. 7%) with hypertension,36 cases( 30. 0%) with affective disorder,27 cases( 22. 5%) with affective disorder and no degenerative disease,22 cases( 18. 3%) with diabetes mellitus,19 cases( 15. 8%) with cerebral infarction,14 cases( 11. 7%) with hyperlipidemia and 10 cases( 8. 3%) with coronary heart disease. There were 3 cases with tension headache,vascular dementia and epilepsy( about 2. 5% each). In addition,5-HT syndrome,hypoxic ischemic encephalopathy,chronic renal insufficiency,Sjogren’ s syndrome,restless legs syndrome,non organic insomnia,lung cancer,arrhythmia,hypothyroidism and hyperthyroidism were each found in 1 case( each accounting for about 0. 8%). 2) In this study,among the 39 patients with RBD combined with neurodegenerative disease,19 patients( 48. 7%) combined with PLMS.Among the 120 RBD patients mentioned above,46 cases had periodic limb movements,accounting for 38. 3%,among which 19 had neurodegenerative diseases,accounting for 41. 3%. Among the 74 patients without periodic limb movement,20 patients had neurodegenerative disease accounted for 27. 0%. Conclusion: 1. The incidence of neurodegenerative disease,hypertension,mood disorders,diabetes,cerebral infarction,hyperlipidemia,coronary heart disease and other complications in RBD patients is high,among which neurodegenerative disease is the leading one. 2. The presence of periodic limb movements in RBD patients may indicate a higher risk of neurodegenerative disease.更多还原