【摘要】 目的:探讨社交焦虑障碍(SAD)患者的社交障碍与认知功能的关系。方法:对60例SAD患者(SAD组)及60名性别、教育程度和年龄匹配的健康对照者(正常对照组)进行成套神经认知功能[包括威斯康辛卡片分类测验(WCST)、持续操作功能测试(CPT)、踪迹描绘测验(TMT)、词语流畅性测验(WFT)和听觉词语学习测验(AVLT)]评估及比较;并对患者进行利博维茨社交焦虑量表(LSAS)、状态-特质焦虑量表(STAI)及贝克抑郁量表第2版(BDI-II)临床评估;采用皮尔逊相关性对SAD患者临床状况评分与神经心理测试指标进行相关性分析。结果:SAD组WCST测试的完成分类数的测试分(5.2±1.4)明显低于正常对照组(5.3±0.6),持续性错误数(1.6±2.7)明显高于正常对照组(0.7±0.7)(P均<0.05); LSAS评分(63.5±25.5)明显高于正常值(28.4±21.5);SAD组LSAS评分与WCST的持续性错误数呈正相关(r=0.535,P<0.05),与WCST分类成绩呈负相关(r=-0.353,P<0.05)。结论:SAD患者认知功能中的执行能力明显降低,并与SAD严重程度相关。更多还原

【Abstract】 Objective:To investigate the correlation between social disorder and cognitive function in patients with social anxiety disorders(SAD). Method:60 SAD patients(SAD group) and 60 gender-,education-and age-matched healthy subjects(control group) were enrolled in the study.Both of the two groups were assessed by neuropsychological and clinical methods.The neuropsychological assessments included Wisconsin card sorting test(WCST),the continuous performance test(CPT),the trail-making test(TMT),the word fluency test(WFT) and the auditory verbal learning test(AVLT).The clinical assessments include Liebowitz social anxiety scale score(LSAS) and Beck depression inventory-decond edition score(BDI-II).The correlation between the neuropsychological and clinical methods were also analyzed. Results:The WCST categories completed of SAD group(5.2±1.4)were significantly lower than those of the control group(5.3±0.6)(P<0.05).However the WCST perseverative errors of SAD group(1.6±2.7) were significantly higher compared to the control group(0.7±0.7)(P<0.05).LSAS(63.5±25.5)was significantly higher than the norm(28.4±21.5).LSAS showed significantly positive correlation with perseverative errors in WCST(r=0.535,P<0.05)and significantly negative correlation with the WCST categories completed(r=-0.353,P<0.05). Conclusion: The cognitive function of patients with SAD is significantly low,mainly in executive function and the lower executive function correlates with the severity of social anxiety disorder.更多还原