【摘要】 目的探讨昆明地区成人尿碘水平及与甲状腺疾病的关系。方法选取2018年1月1日至2018年12月30日在昆明市第一人民医院甘美医院内分泌科门诊或体检,年龄大于等于18周岁、同意且签署知情同意书的本地居民266例,分为无甲状腺疾病组,结节组,桥本氏病组,桥本合并结节组,检测TT3、TT4、FT3、FT4、TSH、TPOAb、TgAb、尿碘、甲状腺超声等,分析甲状腺疾病与尿碘的关系。结果 (1)多组间年龄、尿碘组间有统计学差异(P<0.05,),两两比较,结节组、桥本氏甲状腺炎组、桥本合并甲状腺结节组分别与正常组比较,年龄、尿碘均有统计学差异(P<0.05);(2)碘缺乏占23.68%,碘适量占66.54%,碘过量占9.78%。不同尿碘水平中各甲状腺疾病的检出率有差异(χ~2=15.125,P=0.019)碘过量、碘缺乏与碘适量比较,甲状腺疾病检出率有统计学差异(P<0.05);(3)不同年龄段各甲状腺疾病的检出率有差异(χ~2=26.650,P=0.000),年龄<45岁与年龄>59岁的人群中,甲状腺疾病的检出率有统计学差异(P=0.000),其中甲状腺结节、桥本合并结节的检出率随着年龄增加检出率逐渐增加。结论尿碘水平与甲状腺结节、桥本氏甲状腺炎、桥本合并结节成U型关系,随着年龄的增加,甲状腺结节的检出率逐渐增加。更多还原

【Abstract】 Objective To investigate the relationship between the urinary iodine levels and thyroid diseases in adults in Kunming. Methods A total of 266 residents aged 18 years or older who came to see a doctor or had the physical examination and agreed and signed the informed consent were investigated in the Endocrinology Department of Ganmei Hospital affiliated to the First People’s Hospital of Kunming from January 1,2018 to December 30,2018. All subjects were divided into group without thyroid disease, thyroid nodular group,Hashimoto’s disease group, and Hashimoto’s combined nodule group. All subjects were tested for TT3, TT4, FT3, FT4, TSH,TPOAb, Tg Ab, urine iodine, and thyroid ultrasound Etc to analyze the relationship between thyroid disease and urinary iodine. Results(1) There were statistical differences in age and urinary iodine groups among multiple groups(P < 0.05). Pairwise comparison: Compared with normal ones,There were statistically significant differences in age and urine iodine in nodule group, Hashimoto’s thyroiditis group and Hashimoto thyroid nodule group(P < 0.05);(2) Iodine deficiency accounted for 23.68%, moderate iodine accounted for 66.54%,and iodine excess accounted for 9.78%. The detection rate of each thyroid disease was different in different urine iodine levels(χ~2= 15.125, P = 0.019);There was a statistically significant difference in the detection rate of thyroid disease(P < 0.05);(3) The detection rate of thyroid diseases was different in different age groups (χ~2= 26.650, P =0.000). There was a statistically significant difference in the detection rate of thyroid diseases among people aged <45 years and 59 years old(P = 0.000). The detection rate of thyroid nodules and Hashimoto’s combined nodules increased with age. Conclusion There is a U-shaped relationship between the urinary iodine level and thyroid nodules, Hashimoto’s thyroiditis and Hashimoto’s combined nodules and with the increase of age, the detection rate of thyroid nodules gradually increases.更多还原