【摘要】 目的探讨矮小症儿童和青少年血尿酸(UA)与丙氨酸转氨酶(ALT)的相关性。方法本研究纳入了山东省生长发育疾病随访研究队列中诊断为矮小症的685例患者,收集其基线临床资料,横断面分析矮小症儿童和青少年UA与ALT的相关性。结果单因素分析显示UA与ALT呈正相关(P<0.05);校正了混杂因素以后,通过平滑曲线拟合发现UA与ALT呈曲线关系,UA的拐点为6.47mg/dl,当UA<6.47mg/dl时,UA每增加1mg/dl,ALT降低0.04U/L(95%CI:-0.69～0.76; P=0.924);当UA≥6.47mg/dl时,UA每增加1mg/dl,ALT增加3.62U/L(95%CI:0.85～6.40; P=0.011)。结论在矮小症儿童和青少年中,UA水平与ALT的水平存在曲线关系。更多还原

【Abstract】 Objective To investigate the association between uric acid(UA) and alanine aminotransferase(ALT) in children and adolescents with short stature.Methods This study included 685 patients diagnosed as short stature in the follow-up study cohort of growth and development diseases in Shandong Province.The baseline clinical data were collected and the correlation between UA and ALT in children and adolescents with short stature was analyzed by cross-sectional analysis.Results Univariate analysis showed that UA and ALT were positively associated(P<0.05); after adjusting for confounding factors,smooth curve fitting found that UA and ALT were in a curve relationship.The inflection point of UA was 6.47 mg/dl,when UA<6.47 mg while UA increases by 1 mg/dl,ALT decreases by 0.04 U/L(95%CI:-0.69 ～0.76;P=0.924);when UA≥6.47 mg/dl,while UA increases by 1 mg/dl ALT increases by 3.62 U/L(95%CI: 0.85～6.40;P=0.011).Conclusion In children and adolescents with short stature,we found a nonlinear relationship between UA and ALT.更多还原