【摘要】 目的分析新生儿维生素A水平的现状及不同因素对新生儿维生素A水平的影响。方法选择2019年1月～2019年2月在该院新生儿重症监护病房住院的137例新生儿,采用高效液相色谱法测定新生儿维生素A水平,分析不同因素对维生素A水平的影响。结果①137例住院新生儿维生素A水平为(0. 27±0. 15) mg/L。根据维生素A缺乏的诊断维标准,维生素A缺乏46例,比例占33. 6%。②胎龄28～32周组、32～34周组、34～37周组、胎龄≥37周组维生素A水平分别为(0. 24±0. 13) mg/L、(0. 23±0. 15) mg/L、(0. 26±0. 15) mg/L、(0. 32±0. 15) mg/L。不同胎龄新生儿维生素A缺乏发生率差异无统计学意义(P> 0. 05);极低出生体重组、低出生体重组和正常出生体重组维生素A水平分别为(0. 22±0. 15) mg/L、(0. 23±0. 13) mg/L、(0. 31±0. 15) mg/L,低出生体重组维生素A缺乏比极低出生体重组和正常体重组的发生率高,差异有统计学意义(χ2=53. 63,P <0. 05)。极低出生体重组重度维生素A缺乏比低出生体重组和正常体重组的发生率高,差异有统计学意义(χ2=49. 94,P <0. 05);血糖、感染亦是影响维生素A水平的因素,差异有统计学意义(P <0. 05);性别、呼吸窘迫综合征、高胆红素血症与新生儿维生素A水平无相关性(P> 0. 05);感染(OR=3. 046,95%C 1. 152～8. 148,P=0. 025)、出生体重(OR=2. 872,95%C1:1. 062～7. 770,P=0. 038)是维生素A缺乏的危险因素。结论新生儿维生素A缺乏发生率较高,发生感染的新生儿及低出生体重儿更容易发生维生素A缺乏。更多还原

【Abstract】 Objective To analyze the present situation of neonatal vitamin A level and neonatal vitamin A levels at different gestational age and birth weight. Methods A total of 137 neonates hospitalized in neonatal intensive care unit of our hospital from January 2019 to February2019 were selected. Vitamin A levels of neonates were determined by high-efficiency lacquer chromatography,and the effects of different factors on vitamin A levels were analyzed. Results①The vitamin A level of 137 hospitalized newborns was( 0. 27 ± 0. 15) mg/L. According to the diagnostic criteria of vitamin A deficiency,there were 46 cases of vitamin A deficiency,accounting for 33. 6% . ②Vitamin A level was( 0. 24 ± 0. 13) mg/L in group whose gestational age( GA) from 28 w to 32 w; Vitamin A level was( 0. 23 ± 0. 15) mg/L in group whose gestational age( GA) from 32 w to 34 w; Vitamin A level was( 0. 26 ± 0. 15) mg/L in group whose gestational age( GA) from 34 w to 37 w; Vitamin A level was( 0. 32 ± 0. 15) mg/L in group whose gestational age( GA) was no less than 37 w. Vitamin A levels were( 0. 22 ± 0. 15) mg/L,( 0. 23 ± 0. 13) mg/L,( 0. 31 ± 0. 15) mg/L in the very low birthweight group,the low birthweight group and the normal birth weight group,respectively. The incidence of vitamin A deficiency in the low birthweight group was higher than that in the very low birthweight group and the normal weight group,and the difference was statistically significant( χ2= 53. 63,P <0. 05). The incidence of severe vitamin A deficiency was higher in the very low birth weight group than in the low birth weight group and the normal weight group,and the difference was statistically significant( χ2= 49. 94,P < 0. 05). Blood glucose and infection were also factors affecting vitamin A levels,with statistically significant differences( P < 0. 05). There was no correlation between gender,respiratory distress syndrome,hyperbilirubinemia and neonatal vitamin A level( P > 0. 05). Infection( OR = 3. 046,95% C 1. 152 ～ 8. 148,P = 0. 025) birth weight( OR = 2. 872,95% C1: 1. 062 ～ 7. 770,P = 0. 038) were risk factors for vitamin A deficiency. Conclusion The incidence of neonatal vitamin A deficiency is high. Low birth weight infants and very low birth weight infants are more likely to suffer from vitamin A deficiency. Infections and low birth weight are more likely to cause vitamin A deficiency.更多还原