【摘要】 目的研究分析轻度认知功能障碍(MCI)肾精亏虚证患者的认知损害特点及其相关因素。方法选取60例MCI肾精亏虚证患者为观察组,并选取60例认知功能正常者为对照组。首先对观察组患者采用蒙特利尔认知评估量表(MoCA)对患者的认知功能异常情况进行测评,包括延迟回忆、语言、命名、定向、注意计算、抽象思维及视空间与执行功能,通过分析MCI肾精亏虚证证型积分与MoCA各项评分的相关性,得出其主要认知功能损害特点。然后对2组的详细资料情况进行比较,包括年龄、性别、教育程度、婚姻状况、职业性质、经济状况、吸烟、饮酒、体育锻炼、睡眠质量、原发性高血压、糖尿病、高脂血症、心脏病、脑血管疾病、心理疾病及家族史,分析筛选其中可能是影响发生肾精亏虚证MCI的相关因素,并进行相关性分析。结果经Spearman相关系数检验分析显示,MCI肾精亏虚证积分与MoCA量表中延迟回忆、命名、定向、注意计算及视空间与执行功能评分比较差异有统计学意义(P <0.05),存在相关性,而与语言及抽象思维评分比较差异无统计学意义(P>0.05)。2组在教育程度、婚姻状况、饮酒、体育锻炼、睡眠质量、原发性高血压、糖尿病、高脂血症及心理疾病方面比较差异有统计学意义(P <0.05)。进一步进行Logistic回归分析结果显示,MCI肾精亏虚证的发生与患者的受教育程度、饮酒、体育锻炼、睡眠质量、糖尿病、高脂血症及心理疾病情况具有相关性(P <0.05),而与婚姻状况及原发性高血压情况无相关性(P> 0.05)。结论 MCI肾精亏虚证患者的认知损害特点主要表现在延迟回忆、命名、定向、注意计算及视空间与执行功能方面,其发生与患者的受教育程度、饮酒、体育锻炼、睡眠质量、糖尿病、高脂血症及心理疾病情况密切相关。更多还原

【Abstract】 Objective To study and analysis the characteristics and related factors of cognitive impairment in patients with mild cognitive impairment(MCI) of kidney essence deficiency syndrome.Methods 60 patients with MCI kidney essence deficiency syndrome were selected as the observation group,and 60 patients with normal cognitive function were selected as the control group.First of all,Montreal cognitive assessment scale(MoCA) was used to evaluate the cognitive dysfunction of patients in the observation group,including delayed recall,language,naming,orientation,attention calculation,abstract thinking,visual space and executive function.By analyzing the correlation between MCI kidney essence deficiency syndrome type score and MoCA scores,the main cognitive impairment characteristics were obtained.Then the detailed data of the two groups were compared,including age,gender,education level,marital status,occupational nature,economic status,smoking,drinking,physical exercise,sleep quality, hypertension, diabetes, hyperlipidemia, heart disease,cerebrovascular disease,psychological disease and family history,and screen the related factors that may affect the occurrence of kidney essence deficiency syndrome MCI,and conduct correlation analysis.Results The Spearman correlation coefficient test showed that there were significant differences between MCI score of kidney essence deficiency syndrome and scores of delayed recall,naming,orientation,attention calculation,visual space and executive function score in MoCA scale(P < 0.05),but there was no significant difference between MCI score and language and abstract thinking score(P > 0.05).There were significant differences in education,marital status,drinking,physical exercise,sleep quality,hypertension,diabetes,hyperlipidemia and psychological diseases between the two groups(P < 0.05).Further Logistic regression analysis showed that the occurrence of MCI kidney essence deficiency syndrome was correlated with education level,drinking,physical exercise,sleep quality,diabetes,hyperlipidemia and psychological disease(P < 0.05),but not with marital status and hypertension(P > 0.05).Conclusion The cognitive impairment of MCI patients with kidney essence deficiency syndrome is mainly manifested in delayed recall,naming,orientation,attention calculation,visual space and executive function.The occurrence of cognitive impairment is closely related to the education level,drinking,physical exercise,sleep quality,diabetes,hyperlipidemia and psychological diseases.更多还原