【摘要】 目的 :探讨雷公藤多苷联合雷米普利治疗老年原发性肾病综合征(PNS)的效果。方法 :选取2016年10月—2018年4月我院收治的102例老年PNS患者,按随机数字表法分为观察组与对照组,各51例。常规干预及治疗基础上,对照组给予雷米普利(2.5 mg,qd)治疗,观察组给予雷米普利+雷公藤多苷(20 mg,tid)治疗,两组均连续治疗8周。比较两组临床疗效、治疗前后肾功能指标[24 h尿蛋白定量、血清尿素氮(BUN)、肌酐(Scr)]及血清免疫球蛋白(IgA、IgM、IgG)水平,比较两组治疗期间不良反应发生率。结果 :观察组治疗总有效率高于对照组,差异有统计学意义(P <0.05);治疗后观察组24 h尿蛋白定量、血清BUN、Scr水平低于对照组,差异有统计学意义(P <0.05);治疗后观察组血清IgA、IgG水平高于对照组,IgM水平低于对照组,差异有统计学意义(P <0.05);治疗期间两组不良反应发生率比较差异无统计学意义(P> 0.05)。结论 :雷公藤多苷与雷米普利联合治疗老年PNS的效果显著,可改善患者的肾功能,提高机体免疫功能,且安全性好。更多还原

【Abstract】 Objective: To explore the effect of tripterygium glycosides combined with ramipril in the treatment of senile primary nephrotic syndromes(PNS). Methods: 102 elderly patients with PNS admitted to our hospital from October 2016 to April 2018 were selected and randomly divided into an observation group and a control group, 51 cases each. Based on conventional intervention and treatment, the patients in the control group were treated with ramipril(2.5 mg, qd), and the patients in the observation group were treated with ramipril and tripterygium glycosides(20 mg, tid). The patients in the two groups were treated continuously for 8 weeks. The clinical efficacy and the levels of renal function indexes [24-hour urine protein quantification, serum urea nitrogen(BUN), creatinine(Scr)] and serum immunoglobulins(IgA, IgM, IgG) before and after treatment were compared between the two groups, and the incidence of adverse reactions was also compared between the two groups. Results: The total effective rate of the treatment in the observation group was higher than that in the control group, and the difference was statistically significant(P<0.05). After treatment, the levels of 24-hour urine protein quantification, serum BUN and Scr in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). After treatment, the levels of serum IgA and IgG in the observation group were higher than those in the control group, and the level of IgM was lower than that in the control group, with statistically significant differences(P<0.05). There was no statistically significant difference in the incidence of adverse reactions(P>0.05). Conclusion: Tripterygium glycosides combined with ramipril have a significant effect on the elderly patients with PNS, which can improve the renal functions of the patients and improve their immune function, and have good safety.更多还原