【摘要】 目的:依据Beers标准及STOPP/START标准对老年住院患者用药合理性评价的结果进行比较分析,为建立我国老年人不适当用药点评标准作参考。方法:分别以Beers标准及STOPP/START标准为依据,对某三级甲等医院300例老年住院患者的潜在性不适当用药(PIM)进行评价,利用χ~2检验对STOPP/START标准点评所得的PIM发生率进行单因素分析,利用Kappa检验对两标准点评结果进行一致性检验。结果:依据STOPP/START标准,65例(21. 7%)老年患者至少存在一种PIM;108例(36%)老年患者至少存在一种潜在性处方遗漏(PPO);影响因素分析结果表明,男性、年龄70～79岁、罹患疾病数≥4、用药品种数> 10均使潜在不适当用药的发生率增加(P=0. 000)。两种标准PIM发生率一致性较差,Kappa=0. 026 4。结论:Beers标准与STOPP/START标准在评估老年住院患者潜在性不适当用药风险中均有重要价值,但两者侧重点不同,联合使用可能会进一步提高老年人合理用药水平。更多还原

【Abstract】 Objective: To analyze the potential inappropriate medication( PIM) in elderly inpatients in a grade A tertiary hospital evaluated respectively by Beers criteria and STOPP/START criteria to compare the differences between them. Methods:A total of 300 elderly inpatients were involved and received the screening of PIM respectively according to Beers criteria(2012)and STOPP/START criteria. Chi-square analysis was used for the single factor analysis,and Kappa test was used in the consistency check. Results: According to STOPP/START criteria,the incidence of PIM and PPO was 21. 7% and 36%,respectively. The incidence of PIM increased in the male inpatients in the age of 70-79 with more than four diseases and treated with more than 10 drugs( P = 0. 000). The consistency of the two criteria for the evaluation of PIM was poor,and Kappa was0. 026 4. Conclusion: Both of the criteria can be used for the analysis of PIM in elderly inpatients with different focus. The combination of the two criteria may further improve the rational drug use.更多还原