【摘要】 目的探讨抗精神病药物对长期住院男性慢性精神分裂症患者合并代谢综合征的影响。方法 325例长期住院男性慢性精神分裂症患者,根据抗精神病药物种类不同分为氯丙嗪组(41例)、氯氮平组(94例)、奥氮平组(50例)、利培酮组(68例)及联合用药组(72组);根据抗精神病药物剂量不同分为≤200 mg/d组(76例)、200～400 mg/d组(164例)及≥400 mg/d组(85例)。比较不同抗精神病药物种类组及抗精神病药物剂量组患者代谢综合征发生情况。结果 325例患者中合并代谢综合征124例,代谢综合征发生率为38.15%。氯丙嗪组患者代谢综合征发生率为29.27%,氯氮平组为39.36%,奥氮平组为48.00%,利培酮组为45.59%,联合用药组为27.78%,比较差异无统计学意义(χ~2=8.362, P=0.079>0.05)。≤200 mg/d组患者代谢综合征发生率为38.16%, 200～400 mg/d组为39.63%,≥400 mg/d组为35.29%,比较差异无统计学意义(χ~2=0.447, P=0.800>0.05)。结论抗精神病药物种类及其剂量对长期住院男性慢性精神分裂症患者合并代谢综合征发生率的影响无明显差异。更多还原

【Abstract】 Objective To discuss the effect of antipsychotics on metabolic syndrome in long-term hospitalized male patients with chronic schizophrenia. Methods A total of 325 long-term hospitalized male patients with chronic schizophrenia were divided by different types of antipsychotic drugs into chlorpromazine group(41 cases), clozapine group(94 cases), olanzapine group(50 cases), risperidone group(68 cases) and combination group(72 cases). They were divided by different doses of antipsychotic drugs into ≤200 mg/d group(76 cases), 200-400 mg/d group(164 cases) and ≥400 mg/d group(85 cases). The occurrence of metabolic syndrome in different antipsychotic drug groups and antipsychotic drug dosage groups was compared. Results Among 325 patients, 124 cases were complicated with metabolic syndrome, and the incidence of metabolic syndrome was 38.15%. The incidence of metabolic syndrome was 29.27% in chlorpromazine group, 39.36% in clozapine group, 48.00% in olanzapine group, 45.59% in risperidone group, and 27.78% in combination group. Their difference was not statistically significant(χ~2=8.362, P=0.079>0.05). The incidence of metabolic syndrome was 38.16% in the < 200 mg/d group, 39.63% in the 200-400 mg/d group and 35.29% in the < 400 mg/d group, and the difference was not statistically significant(χ~2=0.447, P=0.800>0.05). Conclusion There was no significant difference in the effects of antipsychotic drugs and their doses on the incidence of metabolic syndrome in long-term hospitalized male patients with chronic schizophrenia.更多还原