【摘要】 "Warburg效应"是肿瘤细胞重要的代谢特征之一,肿瘤细胞在氧气充足的条件下仍进行糖酵解,亦称"有氧糖酵解"。愈来愈多的研究表明肿瘤是一种代谢性疾病。因此探索肿瘤代谢变化及机制,以及靶向肿瘤代谢的肿瘤治疗成为近年来肿瘤研究的热点。目前基于肿瘤代谢的一些治疗方法(如生酮疗法、大剂量维生素C等)逐步引起基础研究和临床研究工作者的重视。最近有研究报导,甘露糖可以抑制肿瘤生长、增加阿霉素抗癌效果和延长荷瘤小鼠生存期。其主要作用机制是干扰葡萄糖代谢、促进肿瘤细胞凋亡以及增强化疗药物顺铂和阿霉素的抗肿瘤作用。此外,甘露糖还有调节免疫平衡等作用。甘露糖作为一种营养素,对人体健康无害,有望成为一种重要肿瘤代谢调节治疗的营养素,并且可与一线肿瘤治疗(化疗和放疗)配合来提高抗肿瘤治疗效果,具有重要的临床意义和应用前景。更多还原

【Abstract】 "Warburg effect" is one of the important metabolic characteristics of tumor cells.Tumor cells still undergo glycolysis under the condition of sufficient oxygen,which is also known as "aerobic glycolysis".Many studies have shown that cancer is a metabolic disease.Therefore,to explore the changes and mechanisms of tumor metabolism,as well as tumor metabolic regulation therapy targeting tumor metabolism,have become a focus of tumor research in recent years.At present,some treatment methods based on tumor metabolism,such as ketogenic therapy and high-dose vitamin C,have gradually attracted the attention of basic research and clinical research.Recently,it has been reported that mannose can inhibit tumor growth,increase the anti-cancer effect of adriamycin and prolong the survival period of tumor-bearing mice.It mainly interferes with glucose metabolism and enhances the anti-tumor effect of chemotherapy drugs cisplatin and adriamycin to promote tumor cell apoptosis.In addition,mannose still has the effect of regulating immunity balance.Mannose,as a nutrient,is harmless to human health,and is expected to become an important nutrient for tumor metabolism regulation therapy,and can be combined with first4 ine tumor therapy(chemotherapy and radiotherapy) to improve the anti-tumor treatment effect,which has important clinical significance and application prospect.更多还原