【摘要】 目的利用受试者工作特征曲线(ROC)评价血清miRNA-155-5p及miRNA-133a-3p表达对脓毒症心肌损伤的诊断价值。方法前瞻性收集江苏大学附属医院收治的脓毒症患者,根据心脏超声分为对照组(n=48例)和心肌损伤组(n=40例)。检测88例脓毒症患者血清miRNA-155-5p及miRNA-133a-3p的表达量,采用ROC曲线评价血清miRNA-155-5p及miRNA-133a-3p对脓毒症心肌损伤的诊断价值。结果与对照组比较,脓毒症心肌损伤组患者的miRJNA-155-5p [(2.02±0.45) vs.(2.89±0.37)]和miRNA-133a-3p [(1.93±0.37)vs.(2.42±0.22)]表达量均明显增高(P<0.05)。ROC曲线分析提示,miRNA-155-5p(AUC=0.92,95%CI 0.86～0.97,P=0.028,敏感度97.50%,特异度72.92%)和miRNA-133a-3p(AUC=0.87,95%CI 0.80～0.95,P=0.040,敏感度95.00%,特异度70.00%)对脓毒症患者心肌损伤有较高的诊断价值。结沦血清miRNA-155-5P及miRNA-133a-3p的表达有助于诊断脓毒症心肌损伤。更多还原

【Abstract】 Objective To evaluate the diagnostic value of serum miRNA-155-5 p,miRNA-133 a-3 p for myocardial injury in sepsis.Methods Septic patients admitted to the hospital were divided into control group(n=48) and myocardial injury group(n=40) according to cardiac ultrasound.The level of serum miRNA-155-5 p and miRNA-133 a～3 p were also detected.The diagnostic value of the level of serum miRNA-155-5 p and miRNA-133 a-3 p was analyzed by ROC curve.Results Compared with the control group,the expression levels of serum miRNA-155-5 p[(2.02±0.45) vs.(2.89±0.37)]and miRNA-133 a-3 p[(1.93±0.37) vs.(2.42±0.22)] in patients with myocardial injury of sepsis were significantly increased(P <0.05).ROC curve analysis indicated that detection of miRNA-155-5 p(AUC=0.92,95% Cl 0.86～0.97,P=0.028,sensitivity 97.50%,specificity 72.92%) and miRNA-133 a-3 p(AUC=0.87,95% CI 0.80～0.95,P=0.040,sensitivity 95.00%,specificity 70.00%) were of high diagnostic value for myocardial injury in patients with sepsis.Conclusion Detection of the expression of miRNA-155-5 p and miRNA-133 a-3 p in serum is helpful for the diagnosis of myocardial injury in sepsis.更多还原