【摘要】 目的分析烧伤病房内小儿烧伤创面感染细菌分布及抗生素敏感情况。方法收集2010年1月至2017年12月期间安徽医科大学第一附属医院烧伤科病房内符合入选标准的小儿住院烧伤患者共170例。对患儿创面分泌物做细菌培养及药物敏感试验,对菌种分布特点及抗生素敏感性进行分析。结果共检出138株病原菌。其中革兰阴性杆菌以铜绿假单胞菌、鲍氏不动杆菌及大肠埃希菌为主,分别为39株(28. 3%)、22株(16. 0%)、14株(10. 1%);革兰阳性球菌以金黄色葡萄球菌25株(18. 1%)、溶血葡萄球菌14株(10. 1%)为主。另外检出的金黄色葡萄球菌中均为耐甲氧西林金黄色葡萄球菌,仅对替加环素及万古霉素的药物敏感率为100%,对利奈唑胺及喹努普汀-达福普汀的敏感率分别为96. 0%、80. 0%。检出的铜绿假单胞菌对多粘菌素B及米诺环素的药物敏感率为100%,鲍曼不动杆菌对替加环素及多粘菌素B的敏感率为100%。结论在安徽医科大学第一附属医院烧伤小儿住院患者创面感染的菌株前三位分别是铜绿假单胞菌、金黄色葡萄球菌及鲍曼不动杆菌。以革兰阴性杆菌感染为主,并呈现出多重耐药性,只对少数抗生素敏感。建议在预防医源性感染、监测细菌药物敏感情况的条件下,合理应用抗生素。更多还原

【Abstract】 Objective To analyze the bacterial distribution and antibiotic sensitivity of burn wounds in children with burns. Methods From January 2010 to December 2017,a total of 170 inpatients who were met the inclusion criteria in the Department of Burns,First Affiliated Hospital of Anhui Medical University were enrolled. The wound secretion was made into bacterial culture and drug sensitivity test,and the distribution characteristics and antibiotic sensitivity of the strain were analyzed. Results A total of138 strains were detected. Among them, Gram-negative bacilli were mainly Pseudomonas aeruginosa,Acinetobacter baumannii and Escherichia coli,with 39 strains( 28. 3%),22 strains( 16. 0%) and14 strains( 10. 1%),respectively; The positive cocci were mainly composed of 25 strains of Staphylococcus aureus( 18. 1%) and 14 strains of Streptococcus haemolyticus( 10. 1%). In addition,all of the detected Staphylococcus aureus were methicillin-resistant Staphylococcus aureus,the sensitivity to tigecycline and vancomycin was 100%,and the sensitivity to linezolid and quinupristin-dafoptin was 96. 0% and 80. 0%,respectively. The drug sensitivity of Pseudomonas aeruginosa to polymyxin B and minocycline was 100%,and the sensitivity of Acinetobacter baumannii to tigecycline and polymyxin B was 100%. Conclusions The top three strains of wound infection in hospitalized patients with burns in First Affiliated Hospital of Anhui Medical University were Pseudomonas aeruginosa,Staphylococcus aureus and Acinetobacter baumannii.Gram-negative bacilli are predominantly infected and exhibit multi-drug resistance,sensitive to only a few antibiotics. It is recommended to use antibiotics reasonably under the conditions of preventing iatrogenic infections and monitoring bacterial susceptibility.更多还原