【摘要】 目的系统评价代谢综合征与骨关节炎发病风险的相关性。方法通过检索Pubmed,荷兰医学文摘数据库(EMbase),中国生物医学文献数据库(CBM),维普网(VIP),Cochrane图书馆(2018年第5期),中国知网(CNKI),万方(WanFang)等电子数据库,搜集代谢综合征对骨关节炎(OA)发生风险相关性的观察性研究,检索时间均为自建库至2018年5月。由2位作者按照纳入、排除标准(探讨代谢综合征与骨关节炎的相关性为研究主题的观察性研究,并排除重复发表的文献)独立甄选文献、计算数据并进行纳入研究的质量评估后,运用Revman 5. 3软件进行Meta分析。结果最终纳入9篇文献,总共25 096例患者。原始比值比(OR)及95%置信区间(CI)的Meta分析结果显示,患有代谢综合征人群的骨关节炎发病风险是未患代谢综合征人群的2. 23倍[OR=2. 23,95%CI(1. 48,3. 36),P=0. 000 1],校正后的Meta分析结果仍然显示患有代谢综合征人群的骨关节炎发病风险高于未患代谢综合征人群[OR=1. 05,95%CI(1. 03,1. 07),P <0. 01]。结论代谢综合征与骨关节炎发病具有相关性,代谢综合征可增加骨关节炎的发病风险。更多还原

【Abstract】 Objective To systematically assess the relationship between metabolic syndrome and osteoarthritis. Methods Databases including Pub Med,Excerpta Medica Database (EMbase),China Biology Medicine disc (CBM),China Science and Technology Journal Database (VIP),the Cochrane Library (Issue 5,2018),China National Knowledge Infrastructure (CNKI) and Wan Fang Data were searched for the published studies including the investigation of the correlation between metabolic syndrome and osteoarthritis from inception to May 2018. The observational trials about correlation between metabolic syndrome and osteoarthritis were included,and repeat published literatures were excluded. Two authors specifically assessed literature according to the inclusion and exclusion criteria,acquired data and evaluated the risk of bias of involved studies. Meta-analysis was performed using Rev Man 5. 3 software. Results A total of nine studies including 25 096 patients were involved. The results of meta-analysis showed that pooled crude risk of occurrence of osteoarthritis in metabolic syndrome population was 2. 23 times of the non-metabolic-syndrome population[OR = 2. 23,95% CI (1. 48,3. 36),P = 0. 0001 ],and pooled adjusted risk of occurrence of osteoarthritis in metabolic syndrome population was still greater than non-metabolic-syndrome population[OR = 1. 05,95% CI (1. 03,1. 07),P < 0. 01]. Conclusion Metabolic syndrome is associated with osteoarthritis,which increases risk of osteoarthritis.更多还原