【摘要】 目的:分析新疆汉族、维吾尔族抗结核药物相关肝损伤患者临床特征与免疫特征,并比较两民族间的差异。方法:服用抗结核药物诱导的肝损伤患者176例(汉族79例、维吾尔族97例),记录临床资料,采集空腹肘静脉血,流式细胞术检测CD3~+、CD4~+、CD8~+T细胞频率,ELISA检测血清TNF-α、IL-10。结果:在年龄、性别构成、身高、体质量、体质指数、ALT、AST、γGGT、ALP、LDH、TBA、肝损伤出现时间、肝损伤轻重程度占比、肝损伤靶位临床分型等方面两民族间无差异;维吾尔族患者血清Glb、TNF-α、IL-10水平及CD8+T细胞频率均明显高于汉族患者(P=0.001;P<0.001;P<0.001;P<0.001)。结论:提示维吾尔族患者细胞免疫应答强于汉族患者;两个民族肝损伤患者相关临床指标不存在民族间差异。更多还原

【Abstract】 OBJECTIVE To analyze the clinical features and immune characteristics of patients with anti-TB drug-related liver injury among Han and Uygur ethicity population in Xinjiang, and to compare the differences between the two ethnic groups. METHODS 176 patients(79 Han and 97 Uygur) with liver injury induced by antituberculous drugs were enrolled in this study. Clinical data of patients were recorded and the elbow vein blood of fasting was collected. The frequencies of CD3~+, CD4~+ and CD8~+ T cells were detected by flow cytometry. Level of TNF-α and IL-10 in serum were detected by ELISA. RESULTS There were no differences in age, sex, height, weight, body mass index, ALT, AST, γGGT, ALP, LDH, TBA, time of liver injury, proportion of severity of liver injury, and clinical classification of liver injury target sites between the two ethnic groups; serum Glb, TNF-α, IL-10 levels and CD8~+ T cell frequencies in Uygur patients were significantly higher than those in Han patients(P=0.001; P<0.001; P<0.001; P<0.001). CONCLUSION The cellular immune response of Uygur ethicity patients is significantly stronger than that of Han ethicity patients; No significant difference was observed between Han and Uygur ethicity groups.更多还原