【摘要】 目的探讨原发性高血压患者合并非酒精性脂肪肝(NAFLD)与脂联素(APN)及胰岛素抵抗(IR)的关系。方法选取2015年5月～2016年6月潍坊市寒亭区人民医院收治的67例原发性高血压患者作为研究对象,根据是否合并有NAFLD分为脂肪肝组(n=33)和非脂肪肝组(n=34)。比较两组患者的体重指数(BMI)、空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、谷丙转氨酶(ALT)等指标水平,用酶联免疫吸附法(ELISA)测定法检测两组患者血清APN浓度,放免法测定空腹胰岛素(FINS),采用稳态模型(HOMA-IR)法评估IR,并进行比较。结果脂肪肝组的BMI、FBG、TC、TG、LDH-C、ALT、FINS、HOMA-IR均高于非脂肪肝组,而脂肪肝组的HDL-C、APN水平低于非脂肪肝组,差异有统计学意义(P<0.05)。APN与SBP、DBP、TG、HbA1c、FINS、HOMA-IR均成负相关(r=-0.48、-0.36、-0.44、-0.31、-0.32、-0.34,P<0.05)。结论原发性高血压患者合并NAFLD与APN及IR密切相关。更多还原

【Abstract】 Objective To investigate the relationship among insulin resistance, adiponectin(APN) and non-alcoholic fatty liver disease(NAFLD) in patients with essential hypertension(EH). Methods A total of 67 patients with EH treated in Weifang Hanting District People′s Hospital from May 2015 to June 2016 were selected as the subjects, and divided into EH+NAFLD group(with NAFLD, n=33) and EH group(without NAFLD, n=34). The indicators including body mass index(BMI), fasting blood glucose(FBG),total cholesterol(TC), triacylglycerol(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), alanine aminotransferase(ALT) were compared between the two groups. The APN was determined by enzyme-linked immunosorbentassay(ELISA), fasting insulin(FINS)were determined by radioimmunoassay, and IR was assessed by homeostasis model assessment-insulin resistance(HOMA-IR) test. Results The levels of BMI, FBG, TC, TG, LDH-CH, ALT, FINS, HOMA-IR in EH+NAFLD group were higher than those in EH group, and the levels of HDL-C and APN in EH+NAFLD group were lower than those in EH group(P<0.05). The level of ANP was negatively correlated with SBP, DBP, TG, HbA1c, FINS and HOMA-IR in patients with EH(r=-0.48,-0.36,-0.44,-0.31,-0.32,-0.34, P<0.05). Conclusion NAFLD in patients with EH is closely related to APN and Insulin resistance.更多还原