【摘要】 目的探讨血清人附睾蛋白4(HE4)、糖链多肽抗原125(CA125)、卵巢恶性肿瘤风险模型(ROMA)在卵巢上皮性癌诊断中的价值。方法回顾性分析2016年9月至2017年8月在辽宁省肿瘤医院住院的卵巢肿瘤患者247例(包括卵巢上皮性癌139例,卵巢交界性上皮性肿瘤18例,卵巢良性肿瘤90例)及子宫肌瘤患者39例的临床病理资料,检测术前血清CA125及HE4水平,计算ROMA值,分析CA125、HE4及ROMA值与临床病理参数的关系,计算诊断评价指标,绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC)。结果卵巢上皮性癌组HE4阳性率绝经前后均明显高于其他组,差异有统计学意义(P<0.05);CA125阳性率绝经后明显高于其他组,差异有统计学意义(P<0.05);绝经前差异无统计学意义(P>0.05);ROMA阳性率绝经前后差异无统计学意义(P>0.05)。敏感度比较:CA125高于HE4及ROMA;特异度比较:HE4高于CA125和ROMA;正确诊断指数比较:ROMA高于HE4和CA125。结论 HE4联合CA125及ROMA模型对卵巢上皮性癌的诊断价值优于HE4、CA125单项检测。更多还原

【Abstract】 Objective To investigate the value of HE4,CA125 and ovarian malignant tumor risk prediction models(ROMA)in the diagnosis of ovarian epithelial malignant tumors.Methods The clinical and pathological data of 247 patients with ovarian tumors(EOC 139 cases,BOT 18 cases,and benign ovarian tumor 90 cases)and 39 patients with uterine fibroids in Liaoning Tumor Hospital from September 2016 to August 2017 were retrospectively analyzed. The levels of serum CA125 and HE4 were measured before operation. The ROMA values were calculated and the relationship between CA125,HE4,ROMA values and clinical pathological parameters were analyzed. The diagnostic evaluation index was calculated,the receiver operating characteristic(ROC)curve was drawn,and the AUC value was also calculated.Results The positive rate of HE4 in the ovarian epithelial malignant tumor group was significantly higher than that in other groups before and after menopause,the difference being statistically significant(P<0.05).The positive rate of CA125 in the group of malignant epithelial tumor of ovary was significantly higher than that in other groups after menopause,the difference being statistically significant(P<0.05),but there was no statistical difference before menopause(P>0.05).There was no significant statistical difference in the positive rate of ROMA before or after menopause(P>0.05).The sensitivity of CA125 was higher than that of HE4 and ROMA. Specificity of HE4 was higher than that of CA125 and ROMA.Correct diagnosis index of ROMA was higher than that of HE4 and CA125.Conclusion For the diagnosis of ovarian malignant epithelial tumors,the combined detection of serum HE4 and CA125 and ROMA model is superior to the individual detection of HE4 and CA125.更多还原