【摘要】 目的比较新疆地区新疆维吾尔族(简称维族)、汉族胶质瘤Ki-67、S-100和GFAP的表达差异。方法选取新疆维吾尔自治区人民医院神经外科2010年6月至2017年12月收治的经病理明确的胶质瘤260例,其中维族91例(维族组),汉族169例(汉族组)。采用免疫组化Envision法检测两组胶质瘤Ki-67、S-100和胶质纤维酸性蛋白(GFAP)的表达水平。结果汉族组胶质瘤Ki-67、S-100和GFAP表达阳性率分别为78.7%、74.0%、68.6%;维族组胶质瘤Ki-67、S-100和GFAP表达阳性率分别为81.3%、79.1%、70.3%;两组胶质瘤Ki-67、S-100和GFAP表达阳性率均无统计学差异(P>0.05)。Ki-67表达水平与胶质瘤WHO分级均呈明显正相关(rs汉=0.616,rs维=0.742;P<0.001),而S-100表达水平(rs汉=-0.488,rs维=-0.405;P<0.001)和GFAP表达水平(rs汉=-0.533,rs维=-0.384;P<0.001)均与胶质瘤WHO分级呈明显负相关。结论尽管Ki-67表达水平与胶质瘤WHO分级均呈明显正相关,S-100和GFAP表达水平与胶质瘤WHO分级呈明显负相关,但我国新疆地区维族和汉族胶质瘤Ki-67、S-100和GFAP表达水平无明显差异。更多还原

【Abstract】 Objective To compare the expression levels of Ki-67, S-100 and glial fibrillary acidic protein(GFAP) in the gliomas tissues in Xinjiang Uygur and Han patients with astrogliomas. Methods The expression levels of Ki-67, S-100 and GFAP in 260 samples of astrogliomas derived from 91 Uygur and 169 Han patients with astrogliomas were detected by immunohistochemical Envision method. Results The positive rates of Ki-67, S-100 and GFAP in the tumor tissues were 81.32%, 79.12% and 70.33% respectively in91 Uygur patients with astrocytomas, and were 78.70%, 73.96% and 68.64%, respectively in the Han patients with astrocytomas. There was no significant difference in the positive rates of Ki-67, S-100 and GFAP expressions between the two nationalities patients(P>0.05). The expression level of Ki-67 was positively correlated with the WHO grade of gliomas(rsHan= 0.616, rsUygur=0.742, P<0.001), and the expression level of S-100(rsHan=-0.488, rsUygur=-0.405, P<0.001) and the expression level of GFAP(rsHan=-0.533, rsUygur=-0.384, P<0.001) were negatively correlated with WHO grade of gliomas. Conclusion It is suggested that the ethnical factor may no effect on the correlativity between the expression level of glioma-related marker including Ki-67, S-100 and GFAP.更多还原