【摘要】 目的:对新型隐球菌性脑膜炎患者资料进行分析。方法:选取2011年1月-2016年12月98例新型隐球菌性脑膜炎患者资料,对诊疗情况进行分析。结果:临床症状表现为头痛96例(97.96%),颈强直87例(88.78%),发热85例(86.73%),恶心呕吐81例(82.65%)。误诊58例,误诊率为59.18%。脑脊液检查结果显示,颅压增高94例,占95.92%;白细胞>10×106/L 95例,占96.94%。生化检验结果显示,蛋白含量增高93例,占94.90%。33例采用氟康唑或两性霉素B治疗,死亡、自动出院16例,占48.48%;65例采用两性霉素B+伏立康唑或两性霉素B+氟康唑或两性霉素+伏立康唑+氟康唑治疗,死亡、自动出院7例,占10.77%。结论:在新型隐球菌性脑膜炎诊断中,容易出现误诊情况,单一用药治疗效果较差,需多种药物联合治疗。更多还原

【Abstract】 Objective:To analyze the data of patients with cryptococcus neoformans meningitis.Method:The data of 98 patients with cryptococcus neoformans meningitis from January 2011 to December 2016 were selected to analyze the diagnosis and treatment.Result:Clinical symptoms were headache 96 cases(97.96%),87 cases(88.78%) of neck stiffness,85 cases(86.73%) of fever,81 cases(82.65%) of nausea and vomiting.58 cases were misdiagnosed,the rate of misdiagnosis was 59.18%.Cerebrospinal fluid examination showed that cranial pressure increased 94 cases,accounting for 95.92%.White blood cell>10×106/L95 cases,accounting for 96.94%.Biochemical test results showed that protein content increased 93 cases,accounting for 94.90%.33 patients were treated with Fluconazole or Amphotericin B.16 cases died and were discharged from hospital automatically,accounting for 48.48%.65 cases were treated with Amphotericin B+Voriconazole or Amphotericin B +Fluconazole or Amphotericin B+Voriconazole+Fluconazole,7 cases died and were discharged from hospital automatically,accounting for 10.77%.Conclusion:In the diagnosis of cryptococcus neoformans meningitis,misdiagnosis is easy to occur.Monotherapy is less effective and requires multiple drugs.更多还原