【摘要】 幽门螺杆菌在人群中感染非常普遍。全世界约有三分之二人口感染了幽门螺杆菌。长期慢性幽门螺杆菌感染能诱发炎症,如慢性胃炎和溃疡,甚至恶性肿瘤(如黏膜胃癌和相关淋巴组织淋巴瘤)。吸附在胃黏膜上是幽门螺旋杆菌定植宿主和诱发炎症的第一步,在此过程中,细菌很多外膜蛋白发挥了关键作用。本文将重点论述幽门螺杆菌外膜蛋白中的血型结合黏附素(blood-group-antigen-binding adhesin, BabA),并从宿主受体分子、黏附区域晶体结构和酸适应性等方面阐述其在幽门螺杆菌致病过程中的作用。更多还原

【Abstract】 Helicobacter pylori(H. pylori) is a common acquired gastric pathogen and infects almost twothirds of world’s population. Long-term chronic infection can lead to gastritis and duodenal ulcers including gastric cancer or mucosa-associated lymphoid tissue(MALT) lymphoma. Adhesion to the mucosal epithelium is the first step to colonize in host and induce gastric inflammation. A large number of outer membrane proteins(OMPs) were involved in this process including blood-group-antigen-binding adhesin(BabA). This review summarizes interacted partner, the crystallized structure of adherence domain and pH-sensitive adaption of BabA, besides that how BabA’s structure influence H. pylori pathogenesis was also illustrated.更多还原