【摘要】 目的探讨血清尿酸(UA)、同型半胱氨酸(Hcy)、血脂(TC、TG、HDL-c、LDL-c)与老年非瓣膜性心房颤动患者发生急性脑梗死的相关性。方法选择2016年9月至2018年5月间在我院住院的非瓣膜性心房颤动患者200例,按是否合并急性脑梗死分为急性脑梗死组和非急性脑梗死组,记录患者相关临床资料,测定UA、Hcy、TC、TG、HDL-c、LDL-c等相关指标水平,比较两组各项指标的差异,分析两组患者的相关危险因素,筛选出非瓣膜性心房颤动伴急性脑梗死的主要因素,并将有意义指标与急性脑梗死的发生进行logistic回归分析。结果急性脑梗死组患者伴心力衰竭病史、高血压病史、糖尿病史比例较非急性脑梗死组明显升高,两组间差异有统计学意义(P<0.05)。与非急性脑梗死组相比,急性脑梗死组患者血清UA、Hcy、TC、LDL-c、MPV、D-D值显著升高,差异具有统计学意义(P<0.05)。采用二元logistic回归分析示,心力衰竭、高血压、糖尿病、UA、LDL-c、Hcy、D-D是NVAF伴急性脑梗死患者的危险因素。结论 UA、LDL-c、Hcy与NVAF发生急性脑梗死具有相关性,且为非瓣膜性心房颤动伴急性脑梗死的独立危险因素。更多还原

【Abstract】 Objective To investigate the correlation between uric acid( UA),homocysteine( Hcy),serumlipid( TC,TG,HDL-c,LDL-c) and acute cerebral infarction in elderly patients with nonvalvular atrial fibrillation. Methods 200 cases of patients with nonvalvular atrial fibrillation were selected from September 2016 and May 2018 in our hospital. According to the presence of acute cerebral infarction,all the patients were divided into acute cerebral infarction group and the non-acute cerebral infarction group. The relevant clinical data were collected,and the UA,Hcy,TC,TG,HDL-c,LDL-c and other related indicators were detected and compared between the two groups of each index. The related risk factors were analyzed and then screened for the main factors of acute cerebral infarction which was nonvalvular atrial fibrillation,and meaningful index and the occurrence of acute cerebral infarction for logistic regression analysis. Results The proportion of patients with heart failure,hypertension and diabetes in the acute cerebral infarction group was significantly higher than that in the non-acute cerebral infarction group( P<0.05). Compared with the non-acute cerebral infarction group,UA,Hcy,TC,LDL-c,MPV and D-D values of patients in the acute cerebral infarction group were significantly increased with statistically significant differences( P<0.05). Binary logistic regression analysis showed that heart failure,hypertension,diabetes mellitus,UA,LDL-c,Hcy and D-D were risk factors for NVAF patients with acute cerebral infarction. Conclusion UA,LDL-c and Hcy are correlated with acute cerebral infarction in NVAF,and are independent risk factors for non-valvular atrial fibrillation with acute cerebral infarction.更多还原