【摘要】 肾脏不仅是一个排泄器官,而且是参与矿物质代谢调节的重要器官。因慢性肾脏病患病率的不断攀升,慢性肾脏病所继发的矿物质和骨代谢紊乱(mineral and bone disorder,MBD)也亦受到广泛的关注,主要特征为血磷、血钙和甲状旁腺激素水平的异常。越来越多的临床证据表明,CKD-MBD与慢性肾脏病患者的生活质量和预后情况显著相关。国内外肾脏病权威组织亦多次更新CKD-MBD的相关诊疗指南。本文将重点从高磷血症、血管钙化、甲状旁腺功能亢进及其综合治理等方面阐述CKD-MBD的最新诊疗进展。更多还原

【Abstract】 The kidney is not only an excretory organ, but also an important organ involved in the regulation of mineral metabolism. Due to the increasing incidence of chronic kidney disease, mineral and bone disorder secondary to chronic kidney disease(CKD-MBD), characterized by imbalances in serum levels of phosphorus, calcium and parathyroid hormone, is also widely concerned. A growing body of clinical evidence suggests that CKD-MBD is significantly associated with quality of life and prognosis in patients with chronic kidney disease. Domestic and international authoritative organizations of nephrology have updated diagnostic and therapeutic guidance related to CKD-MBD. The present article provides an overview of hyperphosphatemia, vascular calcification, hyperparathyroidism and their comprehensive management in patients with CKD-MBD.更多还原