【摘要】 为了给早期预防和治疗心血管疾病提供参考,利用血管回声跟踪技术研究老年人类风湿关节炎与动脉弹性的相关性。研究对象选择年龄在60～79岁之间的老年人类风湿关节炎患者40例和健康老年人40例,依次作为实验组与对照组。采用ALOKA Prosoundα10.型彩色超声诊断仪对颈动脉和肱动脉内中膜厚度以及弹性相关参数进行检测。结果发现:检测结果中有35例类风湿关节炎患者颈动脉IMT值超过1 mm,有31例健康研究对象颈动脉IMT值超过1 mm;实验组颈动脉IMT和对照组相比差异无统计学意义(p> 0. 05),β、Ep、PWVβ和AI与对照组相比差异有统计学意义(p <0. 05,p <0. 01);实验组与对照组的肱动脉IMT值间无显著差异(p> 0. 05),β、PWVβ与AI间有显著性差异(p <0. 05); ROC曲线分析结果中,两组研究对象动脉弹性参数差异有统计学意义(p <0. 05)。可见类风湿关节炎与老年人颈动脉和肱动脉弹性存在显著相关性,但受年龄的影响,动脉IMT值改变无法体现RA和动脉粥样硬化在统计学上的相关性,根据实验结果可知,可将ET技术当成一种早期发现RA患者动脉弹性功能下降的诊断方法预防心血管疾病。更多还原

【Abstract】 In order to provide reference for early prevention and treatment of cardiovascular diseases,vascular echo tracking technique was used to study the correlation between rheumatoid arthritis and arterial elasticity in the elderly. Subjects of the study included 40 patients with rheumatoid arthritis and 40 healthy elderly,aged between 60 and 79 years,as the experimental group and the control group. The intima-media thickness and elasticity parameters of carotid and brachial arteries were measured by ALOKA Prosound alpha 10. There were significant differences in the IMT value of brachial artery between the experimental group and the control group( p < 0. 05,p < 0. 01). There was no significant difference in IMT value of brachial artery between experimental group and control group( p >0. 05),but there was significant difference between β,Ep,PWVβ and AI( p < 0. 05). There was significant difference between β,PWVβ and AI( p < 0. 05). The results of ROC curve analysis showed that there were significant differences in arterial elastic parameters between the two groups( p < 0. 05). It can be seen that there is a significant correlation between rheumatoid arthritis and carotid and brachial artery elasticity in the elderly,but the change of arterial IMT value does not reflect the statistical correlation between RA and atherosclerosis due to the influence of age. ET can be used as an early diagnostic method to detect the decline of arterial elasticity in patients with RA更多还原