【摘要】 目的研究高血压患者血清25-羟基维生素D[25(OH)D]水平变化及其与血脂相关指标的关系。方法回顾性分析2013年11月～2014年11月在我院住院患者。分为高血压组(A组,n=215);另选同期检查非高血压人群为对照组(B组,n=181)。平行检查两组人群血清25(OH)D、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、载脂蛋白A、B(ApoA、ApoB)、脂蛋白a(Lpa);比较两组间指标水平的差异,分析25(OH)D水平与同组其它指标变化的相关性。结果两组间25(OH)D、TC和TG水平存在统计学差异(P<0.05),其余指标无统计学差异(P>0.05);高血压组25(OH)D平均水平相比对照组低,多因素Logistic回归分析结果显示,年龄、25(OH)D和TG为高血压的独立影响因素;Spearman秩相关性分析结果显示高血压组25(OH)D与TG(r=-0.15791,P=0.0275)呈负相关性。结论高血压患者的血清25(OH)D水平降低与血脂水平升高作为高血压的独立危险因素,参与高血压的发生发展过程。更多还原

【Abstract】 Objective To analyze the relationship between serum levels of 25(OH)D and serum lipid of hypertension. Methods Patients admitted in our hospital from November 2013 to November 2014 were divided into hypertension group(group A, n=215) and the control group(group B, n=181). The serum 25(OH)D blood lipid index, total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL), high density lipoprotein(HDL), apolipoprotein A, B(ApoA, ApoB) and lipoprotein A(Lpa) of the two groups were examined in parallel.The differences in the levels of indicators between the two groups were compared, and the correlation between the levels of 25(OH)D and other indicators in the same group was analyzed. Results There were statistically significant differences in the levels of 25(OH)D, TC and TG between the two groups(P<0.05), and no statistically significant differences in other indicators(P>0.05). The average level of 25(OH)D in the hypertension group was lower than that in the control group. The results of multivariate Logistic regression analysis showed that age 25(OH)D and TG were independent influencing factors of hypertension. Spearman correlation analysis showed that there was a negative correlation between 25(OH)D and TG(r=-0.15791, P=0.0275) in the hypertension group. Conclusion As independent risk factors for hypertension, serum 25(OH)D level reduction and high blood lipid level are involved in the occurrence and development of hypertension.更多还原