【摘要】 目的了解克拉玛依居民维生素D水平现状,为该地区居民防治维生素D缺乏提供依据。方法使用电化学发光法检测25-羟维生素D (25-hydroxy vitamin D,25-OHD),收集2017年克拉玛依市人民医院全部健康检查人群25-OHD数据,比较不同年龄、性别、季节人群25-OHD水平的差异。结果共纳入4 601例研究对象,年龄0. 5～93岁,男女比例1∶2. 38。血清25-OHD的平均水平为(37. 32±21. 78) nmol/L,其中维生素D缺乏、不足、充足人数分别占受检总人数的81. 22%、14. 10%、4. 67%。小于12岁儿童维生素D几乎不缺乏,男女间25-OHD水平比较差异无统计学意义(P>0. 05); 12～19岁青少年25-OHD水平男性高于女性,分别为(41. 65±20. 48)和(28. 02±18. 40) nmol/L,P<0. 05;生育年龄段女性均高于男性,20～34岁组男性和女性25-OHD水平分别为(31. 95±18. 68)和(37. 30±19. 02) nmol/L,35～44岁男性和女性25-OHD水平分别为(30. 20±14. 62)和(36. 75±19. 50) nmol/L,均P <0. 05;更年期及老年组男性25-OHD水平男性均高于女性,但差异无统计学意义(均P>0. 05)。夏、秋、冬三季25-OHD水平男性明显高于女性,P<0. 05;春季比秋季维生素D缺乏明显。结论克拉玛依居民维生素D水平普遍较低,且维生素D水平与年龄、季节及性别都有相关性。更多还原

【Abstract】 Objective To investigate the status of vitamin D in residents of Karamay of Xinjiang province,to provide evidence for prevention and treatment of vitamin D deficiency. Methods 25-hydroxy vitamin D was detected by electrochemiluminescence technique. The data of 25-hydroxy vitamin D were collected from all healthy people of the People’s Hospital of Karamay in 2017. We compared the differences of 25-hydroxy vitamin D levels in different age,gender,and seasonal groups. Results There were 4 601 subjects,aged from 0. 5 to 93 years old,with a male to female ratio of 1 ∶ 2. 38. The average concentration of serum 25-hydroxy vitamin D was(37. 32±21. 78) nmol/L,in which vitamin D deficiency,insufficieny and sufficiency accounted for 81. 22%,14. 10%,and 4. 67% respectively. Children under 12 years old rarely lacked vitamin D,and there was no statistical difference in the level of 25-hydroxy vitamin D between the genders(P>0. 05). In 12 to19 years old group,the level of 25-hydroxy vitamin D in men was higher than that in women [(41. 65±20. 48) vs.(28. 02±18. 40) nmol/L,P<0. 05]. In reproductive age,the levels of 25-hydroxy vitamin D were higher in women than in men [20-34 years old:(37. 30±19. 02) vs.(31. 95±18. 68) nmol/L; 35-44 years old:(36. 75±19. 50) vs.(30. 20±14. 62) nmol/L; all P<0. 05]. In menopause group and elderly group,the levels of 25-hydroxy vitamin D in men were higher than those in women,but there was no statistical difference between them(all P>0. 05). The level of 25-hydroxy vitamin D was significantly higher in males than females in mid-summer,autumn,and winter. The vitamin D deficiency in spring was significantly higher than that in autumn. Conclusion The vitamin D level of the residents of Karamay of Xinjiang province is generally low,and the vitamin D level is correlated with age,gender,and season.更多还原