【摘要】 将乙二醇壳聚糖(GCS)与具有成骨活性的介孔锶羟基磷灰石纳米棒(SrHA)复合后,与多醛基海藻酸钠(OSA)发生席夫碱反应,所得到的水凝胶支架材料可负载唑来膦酸(Zol)并保证该药物的缓慢高效释放。分别制备三组不同SrHA含量(0%、5%、10%)的SrHA-GCS-OSA复合水凝胶,并对其相关性能进行研究。结果表明,三组水凝胶均具有三维网状孔道结构,加入SrHA后棒状纳米粒均匀附着在三维网状孔道结构中;同时,SrHA的存在也会影响孔道直径,可实现孔径的动态调节,从而使其结构特性与人松质骨更加匹配;随SrHA含量的增加,药物缓释作用随之增强;其作为骨组织工程支架材料,具有一定的应用潜力。更多还原

【Abstract】 In this study, we synthesized a composite scaffold based on Zoledronate(Zol) loaded mesoporous strontium hydroxyapatite nanorods(Zol@SrHA) and a hydrogel matrix, which is prepared by exploiting the dynamic reversible Schiff base reaction between OSA and GCS mixed with SrHA nanorods. The results suggested that composite scaffold shows a three-dimensional network structure and the homogeneous deposition of SrHA nanorods. By the addition of SrHA, an enhancement in the comprehensive property of SrHA-incorporated composite scaffolds was observed, which displays controlled-release performance. This study provides an experimental basis for further development of SrHA hydrogel composite scaffold.更多还原