【摘要】 目的:探讨白芍总苷胶囊联合左西替利嗪口服液对慢性特发性荨麻疹(CIU)患儿炎性因子及T淋巴细胞亚群的影响。方法:选取2013年1月至2018年1月仙桃市第一人民医院收治的CIU患儿149例,依据随机数表法分为对照组75例和观察组74例。对照组患儿给予左西替利嗪口服液治疗,观察组在对照组治疗基础上给予白芍总苷胶囊治疗,两组患儿疗程均为1个月,比较两组患儿临床疗效、炎性因子、T淋巴细胞亚群水平及不良反应发生情况。结果:观察组总有效率为98. 65%,高于对照组的89. 33%(P<0. 05)。两组患儿治疗后白细胞介素-4(IL-4)、白细胞介素-17(IL-17)及肿瘤坏死因子-α(TNF-α)水平均低于治疗前(P<0. 05),且观察组低于对照组(P<0. 05)。两组患儿治疗后CD3+、CD4+及CD4+/CD8+水平均高于治疗前,CD8+水平低于治疗前(P<0. 05)。观察组治疗后的CD3+、CD4+及CD4+/CD8+水平高于对照组,CD8+水平低于对照组(P<0. 05)。观察组不良反应的总发生率为14. 86%,与对照组的10. 67%比较差异无统计学意义(P>0. 05)。结论:白芍总苷胶囊联合左西替利嗪口服液治疗CIU患儿疗效较好,用药安全性较高,可能与改善患儿机体的炎性因子及T淋巴细胞亚群状态有关。更多还原

【Abstract】 Objective: To probe into the effects of total glucosides of paeony capsules combined with oral liquid of levocetirizine on inflammatory factors and T lymphocyte subsets in children with chronic idiopathic urticaria( CIU). Methods: Totally 149 children with CIU admitted into Xiantao the First People’s Hospital from Jan. 2013 to Jan. 2018 were extracted to be divided into the observation group and the control group via the random number table,with 74 cases in each group. The control group was treated with oral liquid of levocetirizine,while the observation group was given total glucosides of paeony capsules on the basis of the control group. Both groups were treated for 1 month. Clinical efficacy,inflammatory factors,T lymphocyte subsets and adverse drug reactions of two groups were observed and compared. Results: The total effective rate of the observation group was 98. 65%,significantly higher than 89. 33% of the control group( P<0. 05). After treatment,the levels of interleukin-4( IL-4),interleukin-17( IL-17) and tumor necrosis factor-α( TNF-α) in two groups decreased significantly compared with before treatment( P<0. 05),and the observation group was significantly lower than the control group( P < 0. 05). The levels of CD3+,CD4+and CD4+/CD8+in two groups were significantly higher than before treatment,and the level of CD8+was significantly lower than before treatment( P<0. 05). The levels of CD3+,CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group,and the level of CD8+was significantly lower than the control group( P<0. 05). The total incidence of adverse drug reactions in the observation group was 14. 86%,without any statistically significant difference compared with 10. 67% of the control group( P > 0. 05). Conclusion: The efficacy of total glucosides of paeony capsules combined with oral liquid of levocetirizine in the treatment of children with CIU is significant with higher safety,which may be related to the improvement of inflammatory factors and T lymphocyte subsets in children.更多还原