【摘要】 目的探讨慢性鼻-鼻窦炎(CRS)患者嗅觉障碍的影响因素。方法 334例CRS患者均行T&T嗅觉功能检查,年龄,性别,是否伴发鼻息肉、哮喘、变应性鼻炎和阿司匹林不耐受,吸烟史,先期鼻内镜手术次数采用t检验或卡方检验;嗅觉的多因素相关分析采用Logistic回归分析。结果年龄、性别、吸烟和变应性鼻炎在3种不同嗅觉类型中差异无统计学意义(P>0.05),阿司匹林不耐受、鼻息肉、前期手术次数和哮喘有统计学意义(P<0.05)。多因素Logistic回归分析鼻息肉(回归系数=1.261,P <0.001),阿司匹林不耐受(回归系数=0.98,P=0.008),手术次数(回归系数=0.744,P=0.013),哮喘(回归系数=0.68,P=0.02)对CRS患者嗅觉的影响逐渐增加。结论年龄、性别、吸烟和变应性鼻炎是CRS患者嗅觉下降的非危险因素,阿司匹林不耐受、鼻息肉、前期手术次数和哮喘是CRS患者嗅觉障碍的危险因素。更多还原

【Abstract】 OBJECTIVE To evaluate the relative factors of in?uencing olfactory dysfunction in patients with chronic rhinosinusitis(CRS). METHODS T&T olfactory function was examined in 334 patients with CRS. Age,sex,nasal polyps,asthma,allergic rhinitis,aspirin intolerance,smoking and the frequency of nasal endoscopic surgery were examined by T-test or chi-square test. Logistic regression was used to analyze the related factors of olfactor y.RESULTS There was no signi?cant difference in age,sex,smoking and allergic rhinitis(P >0.05). The difference was statistically signi?cant in Aspirin intolerance,nasal polyps,frequency of nasal endoscopic surgery and asthma(P <0.05).Logistic regression analysis showed that the inf lunce of nasal polyps(B =1.261,P <0.001),aspirin intolerance(B =0.98,P =0.008),times of operations(B =0.744,P =0.013),and asthma(B =0.68,P =0.02) had increased in the CRS patients.CONCLUSION Age,sex,smoking and allergic rhinitis are non-risk factors for olfactory decline in CRS patients.Aspirin intolerance,nasal polyps,the frequency of nasal endoscopic surgery,and asthma are risk factors for olfactory dysfunction in CRS patients.更多还原