【摘要】 目的 :探讨肾上腺素与布地奈德交替雾化吸入治疗小儿急性喉炎合并喉梗阻的临床疗效。方法 :选取2015年1月—2016年12月我院收治的102例急性喉炎合并喉梗阻患儿为研究对象,根据治疗方案的不同分为两组,对照组(50例)采用布地奈德雾化(1.0mg加入2mL 0.9%氯化钠注射液中,雾化吸入)治疗,观察组(52例)采用肾上腺素(1.0 mg加入20 mL 0.9%的氯化钠注射液中,雾化吸入)与布地奈德(同对照组)交替使用,比较两组不同时间临床治疗效果、临床症状改善、住院相关指标及不良反应发生情况。结果 :与对照组比较,观察组治疗的显效率和总有效率明显提高,差异有统计学意义(P <0.05);观察组呼吸困难、声音嘶哑、犬吠样咳嗽以及喉鸣等临床症状的消失时间较对照组明显缩短,差异有统计学意义(P <0.05);观察组住院时间、住院费用明显少于对照组,差异有统计学意义(P <0.05);两组不良反应总发生率比较,差异无统计学意义(P> 0.05)。结论 :肾上腺素与布地奈德交替雾化吸入治疗小儿急性喉炎合并喉梗阻的疗效显著,可迅速缓解临床症状,缩短住院时间,降低住院费用,且安全性较好。更多还原

【Abstract】 Objective: To investigate the clinical efficacy of alternative nebulization inhalation of adrenaline and budesonide in the treatment of acute laryngitis complicated with laryngeal obstruction in children. Methods: 102 children with acute laryngitis complicated with laryngeal obstruction admitted to our hospital from January 2015 to December 2016 were selected as subjects investigated and divided into two groups according to treatment plans. The children in the control group (50 cases) were given budesonide nebulization treatment (1.0 mg added to 2 mL 0.9% sodium chloride injection, nebulization), and the children in the observation group (52 cases) were alternately treated with adrenaline (1.0 mg added to 20 mL 0.9% sodium chloride injection, nebulization) and budesonide (same as control group). The clinical treatment effect, improvement of clinical symptoms, hospitalization-related indexes and occurrence of adverse reactions at different time points were compared between the two groups. Results: Compared with those in the control group, the significant effective rate and total effective rate in the observation group were significantly improved (P<0.05). The disappearance time of symptoms such as dyspnea, hoarseness, barking cough and laryngeal stridor in the observation group was significantly shorter than that in the control group (P<0.05). The hospitalization time and hospitalization cost in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions (P>0.05). Conclusion:Alternative nebulization inhalation of adrenaline and budesonide has significant efficacy in the treatment of acute laryngitis complicated with laryngeal obstruction in children, and can quickly relieve clinical symptoms, shorten hospitalization time and reduce hospitalization costs, and has good safety.更多还原