【摘要】 目的根据当地制定的地中海贫血筛查流程,通过对产科门诊产检的孕妇及配偶进行地中海贫血筛查结果的综合分析,探讨男性配偶参与地中海贫血筛查的必要性。方法在"深圳市妇幼信息系统"中选取在深圳市罗湖区四家医院产科门诊进行初检的所有孕妇25 420例,配合筛查的配偶3626例,包括进行血常规、血红蛋白电泳、地中海贫血基因筛查,并对上述指标的阳性率进行统计分析。结果孕妇与配偶的平均红细胞容积降低的阳性率分别9.8%和11.4%,血红蛋白电泳结果异常的阳性率分别为8.3%和11.9%,地中海贫血基因检测的阳性率分别为11.0%和23.3%,两两分别进行比较,均有统计学差异;且本次研究显示地中海贫血基因人群携带率低于近期其他调查结果。结论在推广地中海贫血防控项目时男性也是重点人群,通过加大宣传力度,以及要求其主动按时按要求的参与此项工作,才能真正有效的降低中重度地中海贫血患儿的出生率。更多还原

【Abstract】 Objective:According to the local thalassemia screening process,through the comprehensive analysis of the results of thalassemia screening for pregnant women and their spouses in obstetric outpatient,the necessity of male spouses participating in thalassemia screening was discussed. Methods:25 420 pregnant women were selected from the department of obstetrics and gynecology of four hospitals in Luohu district of Shenzhen,and 3626 matched spouses were screened,including blood routine、hemoglobin electrophoresis and thalassemia gene screening. The positive rate of these indicators was analyzed statistically. Results:The positive rate of mean corpuscular volume reduction was 9.8 % and 11.4 % in pregnant women and their spouses,and the positive rate of abnormal hemoglobin electrophoresis was 8.3 % and 11.9 % respectively. The positive rate of gene detection was 11.0 % and 23.3 % respectively. There were statistical differences between the two groups. And this study shows that the carrier rate of thalassemia gene population is lower than other recent findings. Conclusion:In the promotion of thalassemia prevention and control project,male is also a key population. Through increasing publicity efforts and requiring their active participation in the work on time,it could reduce the birth rate of children with moderate and severe thalassemia truly and effectively.更多还原