【摘要】 目的:研究五味子乙素对小鼠的抗炎和免疫作用。方法:选取SPF级昆明种小鼠,随机分为空白对照组、模型对照组、阳性对照组(盐酸地塞米松5 mg·kg^-1,盐酸左旋咪唑30 mg·kg^-1)、五味子乙素低剂量组(100 mg·kg^-1)、中剂量组(200mg·kg^-1)和高剂量组(400 mg·kg^-1,盐酸左旋咪唑30mg·kg^-1)。采用二甲苯致炎与环磷酰胺致免疫低下小鼠模型,通过耳肿胀、碳粒廓清和血清血溶素等实验,以肿胀率、肿胀抑制率、碳廓清指数、吞噬指数、半数溶血值、脾指数、胸腺指数等数据为考察指标进行研究。结果:与模型对照组比较,五味子乙素高、中剂量对致炎小鼠的耳肿胀率有显著的抑制作用（P<0.05）,高剂量组与阳性对照组相比差异有统计学意义（P<0.05）;五味子乙素高剂量与模型对照组比较对免疫功能低下小鼠的廓清指数和吞噬指数有显著增加（P<0.05）,且高剂量组廓清指数和吞吐噬指数显著高于低剂量组,差异有统计学意义（P<0.01）,五味子乙素各剂量组与模型对照组相比对免疫功能低下小鼠的半数溶血值有极显著升高（P<0.01）;五味子乙素各剂量组与模型对照组比较对免疫功能低下小鼠的脾指数和胸腺指数均有极显著升高（P<0.01）,且呈剂量依赖型。结论:五味子乙素具有良好的抗炎和增强免疫功能的作用。更多还原

【Abstract】 Objective: To assess the anti-inflammatory and immunomodulatory activities of schisandrin B in mice. Methods: Kunming mice were randomly divided into 6 groups: the blank control group,the model control group,the positive control group( dexamethasone hydrochloride 5 mg·kg^-1,levamisole hydrochloride 30 mg·kg^-1),schisandrin B low( 100 mg·kg^-1),medium( 200 mg·kg^-1) and high( 400 mg·kg^-1) dose groups. The inflammatory mice were induced by xylene and the immunosuppressed mice were induced by cyclophosphamide. The ear edema experiment,carbon clearance experiment and serum hemolysin experiment were performed with the swelling rate,swelling inhibition rate,carbon clearance index,phagocytic index,half hemolytic value,spleen index and thymus index as the investigation factors. Results: High dose and medium dose schisandrin B groups had significant inhibitory effect on mice ear edema when compared with the model control group（ P<0. 05）; There were significant differences between the high dose group and the positive group and there were significant differences in clearance index and phayxyitc index between high dose group and low dose group（ P<0. 05）,and high dose schisandrin B group had increased clearance index and phagocytic index in low immune function mice when compared with the model control group（ P<0. 05）. Schisandrin B significantly increased HC50 in low immune function mice when compared with the model control group（ P<0. 01）. Schisandrin B significantly increased the spleen index and thymus index in low immune function mice when compared with the model control group( P < 0. 01,and in a dose-dependent manner. Conclusion:Schisandrin B has significant anti-inflammatory and immune function enhancing effects.更多还原