【摘要】 胃食管反流(gastresophageal reflux,GER)与慢性咳嗽关系密切,是慢性咳嗽的常见病因。GER可通过微量误吸或食管-支气管反射引起咳嗽,而持续咳嗽又可诱发或加重GER,形成恶性循环。胃食管反流性咳嗽的诊断就是建立GER和慢性咳嗽因果关系的过程,其中食管阻抗-p H监测为最敏感和特异的诊断手段。治疗有效是确定GER和慢性咳嗽因果关系的重要步骤。除生活方式调整外,药物抗反流治疗是目前的第一线治疗,而抗反流手术是有前景的根治疗法。更多还原

【Abstract】 Gastresophageal reflux(GER)is closely associated with chronic cough,and a common cause of chronic cough. Its pathogenesis may involve microaspiration of the refluxate into the airways and esophageal-tracheobronchial reflex originated in the distal esophagus. In turn,cough itself may induce or aggravate GER,leading to a vicious cycle. The diagnosis of cough due to reflux is a process to establish a cause-effect relation between GER and chronic cough,with esophageal impedance-p H monitoring as a most sensitive and specific diagnostic tool. The favorable response to the specific treatment is an important step to confirm GER as the cause of chronic cough. In addition to lifestyle modification,the medical anti-reflux therapy is a first-line choice and anti-reflux surgery is a promising option for cure.更多还原