【摘要】 阿尔茨海默病(Alzheimer’s disease,AD),又称老年痴呆症,是一种神经系统退行性疾病,在老年人中发病率越来越高,是痴呆病中最常见的一类。其临床主要表现为记忆力减退、认知功能障碍,同时影响日常生活。对AD的发病原因并未有明确解释,其中β-淀粉样蛋白聚集被认为是导致AD的重要因素。β-分泌酶(β-site APP cleaving enzyme,BACE)在β位点裂解β淀粉样蛋白前体蛋白(β-amyloid precurgor protein,APP)产生β-淀粉样蛋白(Amyloid protein,Aβ),β-分泌酶影响Aβ的产生。因此,抑制BACE或减少Aβ的产生已经成为防治AD的主要研究方向。目前,对于AD的治疗存在多种假说,是以AD治疗靶点为主,对AD治疗的方法和药物进行研究。更多还原

【Abstract】 Alzheimer’s disease( AD),also known as senile dementia,is a degenerative disease of the nervous system. Its incidence is higher and higher in the elderly,and is the most common type of dementia disease. The main clinical manifestations of Alzheimer’s disease are memory loss,cognitive dysfunction,and affected daily life. The cause of Alzheimer’s disease has not been clearly explained,for which β-amyloid aggregation is considered to be an important factor leading to Alzheimer’s disease. β-secretase( β-site APP cleaving enzyme,BACE) cracks β-amyloid precursor protein( β-amyloid precurgorprotein,APP) at β-site to produce β-amyloid( amyloid protein,Aβ),and β-secretase affects the generation of Aβ. Thus,inhibition of BACE or reduction of Aβ production has become a major research direction for the prevention and treatment of Alzheimer’s disease. At present,there are many hypotheses for the treatment of Alzheimer’s disease,which are based on the treatment target and focused on the treatment methods and drugs.更多还原