【摘要】 目的对不同剂量枸橼酸咖啡因治疗早产儿呼吸暂停(AOP)的临床疗效展开分析。方法 80例AOP患儿,按照随机数字表法分为观察组及参照组,每组40例。两组患儿均采用20 mg/kg枸橼酸咖啡因进行30 min静脉滴注,24 h后,参照组患儿采用枸橼酸咖啡因5 mg/kg维持剂量进行治疗,观察组患儿采用枸橼酸咖啡因10 mg/kg维持剂量进行治疗。比较两组患儿临床治疗效果及不良反应发生情况。结果观察组患儿治疗总有效率为97.50%,高于参照组的67.50%,差异具有统计学意义(χ2=12.4675,P<0.05)。观察组患儿不良反应发生率低于参照组,差异具有统计学意义(χ2=4.1143,P<0.05)。结论使用10 mg/kg维持剂量的枸橼酸咖啡因治疗AOP,能显著提高治疗效果,促进患儿及早康复,临床应用价值较高。更多还原

【Abstract】 Objective To analyze the clinical efficacy of different doses of caffeine citrate in the treatment of apnea of prematurity(AOP). Methods A total of 80 AOP children were divided by random number table method into observation group and control group, with 40 cases in each group. Both groups were treated with intravenous drip of 20 mg/kg citrate for 30 min. After 24 h, the control group was treated with 5 mg/kg maintenance dose of caffeine citrate, and the observation group was treated with 10 mg/kg maintenance dose of caffeine citrate. Comparison were made on clinical treatment effect and occurrence of adverse reactions between the two groups. Results The observation group had higher total treatment effective rate as 97.50% than 67.50% in the control group, and the difference was statistically significant(χ2=12.4675, P<0.05). The observation group had lower incidence of adverse reactions than the control group, and the difference was statistically significant(χ2=4.1143, P<0.05). Conclusion 10 mg/kg maintenance dose of caffeine citrate shows high clinical application value in treating AOP, and it can remarkably improve treatment effect and promote early rehabilitation of children.更多还原