【摘要】 目的回顾性研究2型糖尿病与胃癌发生的相关性,为胃癌的早期诊断及后续研究提供依据。方法收集2010年1月～2015年12月我院收治的胃癌患者523例为胃癌组,随机抽取同期住院的非胃癌患者550例为对照组。本次研究采用病例对照的方法,分析两组以及胃癌组内患者年龄、性别、饮酒、慢性胃炎病史、DM的患病情况以及BMI等因素的差异。结果胃癌组内的糖尿病患病率(13.58%)明显高于对照组(6.91%)(χ~2=13.05,P<0.05);胃癌合并T2DM的患者发病年龄、BMI显著高于胃癌未合并T2DM患者,胃炎病史比例则显著低于未合并T2DM患者(P<0.05);除性别比例外,胃癌组的年龄、BMI、饮酒史比例、胃炎史比例及T2DM患病率均显著高于对照组(P<0.05),多元逐步回归分析后OR值由大到小依次是胃炎史、T2DM患病率、饮酒史、BMI、年龄。结论2型糖尿病患者中发生胃癌的危险性较正常人群明显增加。更多还原

【Abstract】 Objective To retrospectively study the correlation between type 2 diabetes mellitus and gastric cancer and to provide evidence for the early diagnosis and follow-up of gastric cancer. Methods A total of 523 gastric cancer patients admitted in our hospital from January 2010 to December 2015 were selected as the gastric cancer group and 550 non-gastric cancer patients hospitalized at the same time were randomly selected as the control group. The differences of gender, age, history of gastritis, prevalence of DM, alcohol consumption and BMI in two groups of patients and in the patients of the gastric cancer group were analyzed, by taking a case-control approach. Results The prevalence of diabetes mellitus(13.58%) in gastric cancer group was significantly higher than that in control group(6.91%)(χ~2=13.05,P <0.05). The age of onset and BMI of gastric cancer patients with T2 DM was significantly higher than that of gastric cancer patients without T2 DM. The proportion of history of gastritis in the gastric cancer patients with T2 DM was significantly lower than that of gastric cancer patients without T2 DM(P<0.05). The age, BMI, drinking history, gastritis history and prevalence of T2 DM in gastric cancer group was significantly higher than that in control group except for sex ratio(P<0.05). The multivariate stepwise regression analysis showed that the odds ratios(OR) from descending order were gastritis history, T2 DM prevalence, alcohol drinking history, BMI, and age. Conclusion Patients with type 2 diabetes have a greater risk of developing gastric cancer than the normal population.更多还原