【摘要】 目的探讨单孔胸腔镜手术治疗肺癌的临床疗效及对机体创伤程度分析。方法将2016年12月~2017年12月在我院胸外科手术治疗的90例肺癌患者随机分为两组,对照组采用双孔胸腔镜手术,观察组采用单孔胸腔镜手术,比较两组患者的术中术后各项指标、术后并发症发生率、各项血清因子水平。结果观察组手术时间、术中淋巴结清扫数量、术中出血量、术后拔管时间、下床活动时间、术后3 d VAS疼痛评分与对照组相比均有明显差异(P<0.05);观察组术后肺不张、肺部感染、持续液气胸、房颤等并发症发生率与对照组相比无明显差异(P>0.05);观察组术后IL-6、IL-8、TNF-α、CRP、NE、DA、MDA、SOD与对照组相比均有明显差异(P<0.05)。结论单孔胸腔镜手术治疗肺癌的临床疗效显著,手术风险低,手术创伤更小,术后引流量少,有效降低患者术后的疼痛感和炎症应激程度,促进患者快速恢复,具有积极的临床意义。更多还原

【Abstract】 Objective To investigate the clinical effectiveness and degree of trauma to body of single-port(SP) videoassisted thoracoscopic surgery(VAST) in patients with lung cancer. Methods 90 patients with lung cancer who were treated with operation in the department of thoracic surgery of our hospital from December, 2016 to December, 2017 were randomized into two groups. Patients in control groups were treated with double-port(DP) VAST while patients in observation group with SP VAST. Indices during and after operation, incidence of complication and the levels of serum factors after operation were compared between two groups. Results There were significant differences in operation duration, number of intraoperative lymph node dissection, intraoperative bleeding volume, postoperative extubation time,activity time leaving bed and score of postoperative 3 Dvas between two groups(P<0.05). There were no significant differences in the incidence of postoperative atelectasis, pulmonary infection, persistent hydropneumothorax and atrial fibrillation between two groups(P>0.05). There were significant differences in the levels of IL-6, IL-8, TNF-α, CRP, NE,DA, MDA and SOD between two groups(P<0.05). Conclusion The clinical effectiveness of SP VAST in the treatment of lung cancer is significant, with low operation risk, small operative incision and little postoperative volume of drainage.SP VAST could effectively decrease the degree of postoperative pain and inflammatory stress and facilitate patients ’quick recovery. It has positive clinical significance.更多还原