【摘要】 目的探讨脂肪瘤性节细胞神经瘤(LG)的临床病理学特征。方法对3例LG进行临床病理学和免疫表型分析,并复习相关文献。结果 3例LG患者中,2例男性,1例女性。巨检:肿瘤直径9~11 cm,界限清楚,切面灰白、灰黄色,质韧、硬。镜检:肿瘤由成熟的脂肪组织和节细胞神经瘤样结构组成。节细胞神经瘤样结构中可见成熟的神经鞘细胞、神经节细胞和神经纤维。免疫组化:神经节细胞Syn和Cg A(+),神经鞘细胞S-100(+)。结论 LG是一种罕见的良性肿瘤,完整切除是其治疗方式。需与脂肪源性肿瘤、血管平滑肌脂肪瘤鉴别。更多还原

【Abstract】 Objective To investigate the clinicopathological features of lipomatous ganglioneuroma( LG). Methods Three cases of LG were studied for clinicopathological and immunohistochemical features,and the available literature on this subject was reviewed as well. Results Three patients with LG included two males and one female. On macroscopic examination,the well-defined tumors were gray-yellowish on cut surface with rubbery and hard consistence and were 9. 0-11. 0 cm in size. Microscoically,the tumors were composed of mature adipocytes and ganglioneuroma-like structures. There were mature Schwann cells,ganglion cells,and nerve fibres in ganglioneuroma-like structures. Immunohistochemically,the ganglion cells were positive for Syn and Cg A,and the Schwann cells were positive for S-100 protein. Conclusions LG is a rare benign tumor and should be differentiated from adipocytic tumors and angiomyolipoma. The total exicision is the first choice of treatments for LG.更多还原